James W Verbsky, MD,PhD

Associate professor, the Medical College of Wisconsin

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226
414-266-6700 (office)
877-607-5280 (appointment)
130 Second St, West Pavilion
Neenah, WI 54956


Best Doctors 2013As a basic scientist with an interest in defects in the immune system, Dr. Verbsky has actively investigated and defined the genetic causes of patients with severe immune defects. He described a novel autoinflammatory disease due to deficiency in the IL-1 receptor antagonist gene. Recently, together with Drs. Dimmock, Jacob, Mayer, and Worthey, they have described a novel presentation of X-linked lymphoproliferative disease due to a new mutation in XIAP. Studying patients with these rare defects will teach us about the mechanisms of autoimmunity.

Pediatric Rheumatology
Areas of Interest
  • Rheumatology
  • Immune deficiency and dysregulation

Education & Awards

  • 2000, Washington University School of Medicine, MD
  • 2000, Washington University School of Medicine, PhD
  • 2002, St Louis Childrens Hospital (St Louis, MO)
  • 2005, Washington University School of Medicine
  • 2010 - Recipient of the Arthritis Foundation Wisconsin Chapter Research Award
  • 2009 - Recipient of the Department of Pediatrics Clinical Research Award, Medical College of Wisconsin
  • 2009-2012 - Listed in Best Doctors in America
  • 2009 - Recipient of the Dream Makers award, Jeffrey Modell Foundation
  • 2008 - Recipient of the ACR/REF Career Development Bridge Funding Award
  • 2004 - Recipient of the David Gilstrap Fellow Award
  • 2004 - Recipient of the Abbott Scholar Award in Rheumatology Research

Research & Publications

  • Rheumatological disorders
  • Infectious and immunological diseases
  • Human T regulatory cells can use the perforin pathway to cause autologous target cell death.
  • CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes.
  • A novel autoinflammatory disease due to homozygous deletion of the IL-1RN locus; effective treatment with anakinra.
  • Statewide newborn screening for severe T-cell lymphopenia.
  • Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia.
View all publications from James W. Verbsky, MD.