Nita H Salzman, MD,PhD

Investigator, Children's Research Institute
Assistant professor, Medical College of Wisconsin

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 456-4244
(414) 266-3676 (fax)

Overview

Division

  • Gastroenterology and Nutrition

Research interests

  • Gastrointestinal diseases
  • Infectious/immunological diseases

Study interests

  • Antimicrobial peptides
  • Commensal microbiota
  • Defensins
  • Inflammatory bowel disease
  • Innate immunity
  • Intestinal infection
  • Intestinal inflammation
  • Mucosal immunity

Education

  • Medical degree, New York University School of Medicine, 1990
  • Doctorate, New York University School of Medicine, 1990
  • Residency, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 1990-1997
  • Postdoctoral fellowships, Children's Hospital of Philadelphia, 1994-1996, and University of Pennsylvania School of Medicine, 1996-1997

Certifications

  • Pathology
  • Anatomic Pathology

Research & Publications

Research
  • The Regulation of Paneth Cell Defensins by Bacterial Infection, National Institutes of Health, R01, principal investigator
  • SIGIRR, a Negative Regulator of Toll-IL-1R Signaling. NIH, subcontract to Xiaoxia Li, PhD, Cleveland Clinic Foundation, co-investigator

Representative publications 

  • Barman M, Unold D, Shifely E, Amir K, Jung N, Bos A, Salzman NH. Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract. Infection and Immunity. 2008; 76(3):907-915
  • Olivier V, Salzman NH, KJ Fullner, Satchell. Prolonged Colonization of Mice by Vibrio Cholerae El Tor O1 Depends on Accessory Toxins. Infection and Immunity. 2007:;75(10):5043-5051
  • Wehkamp J, Salzman NH, Porter E, Weichenthal M, Petras RE, Shen E, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima K, Fellermann T, Ganz E, Stange F, Bevins CL. Reduced Paneth Cell-defensin Expression in Crohn's Disease of the Ileum. Proceedings of the National Academy of Sciences. 2005; 102(50):18129-18134
  • Salzman NH, Ghosh D, Huttner K, Russell J, Paterson Y, Bevins C. Protection Against Enteric Salmonellosis in Transgenic Mice Expressing a Human Intestinal Defensin. Nature. 2003; 422:522-526. Advance online publication, 19 March 2003 (doi:10.1038/nature01520)
  • Salzman NH, Chou M, deJong H, Liu L, Porter EM, Paterson Y. Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression. Infection and Immunity. 2003; 71(3):1109-1115
  • Salzman NH, deJong H, Paterson Y, Harmsen HJM, Welling GW, Bos NA. Analysis of 16S Libraries of Mouse Gastrointestinal Microflora Reveals a Large New Group of Mouse Intestinal Bacteria. Microbiology. 2002; 148:3651-3660