David A. Wilcox, PhD

Investigator, Children's Hospital of Wisconsin Research Institute

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 456-4998
(414) 456-6543 (fax)

Overview

Division

  • Hematology, Oncology and Transplant

Research center/program

  • Bleeding disorders research

Research interests

  • Bleeding and blood disorders

Study interests

  • Gene therapy
  • Hematopoietic stem cells
  • Inherited bleeding disorders
  • Integrins
  • Platelets

Education

  • Bachelor's degree, Chemistry, University of Wisconsin-Madison, 1987
  • Doctorate, Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, 1994

Education & Awards

Awards

National advisory committees/activities

  • Scientific reviewer, Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis, Blood and Biology of Blood and Marrow Transplantation
  • Ad hoc reviewer, National Institutes for Health Study Section for Hemostasis and Thrombosis

Professional/honorary societies

  • American Heart Association, Scientific Council member
  • American Society of Gene Therapy
  • American Society of Hematology
  • International Society of Thrombosis and Haemostasis.

Research & Publications

Research
  • Therapeutic Expression of a Platelet-specific Integrin, principal investigator (50 percent effort), National Heart Lung and Blood Institute, RO1 HL 068138-03, 2002-2006
  • Molecular and Cellular Mechanisms in Transfusion Medicine, collaborator (10 percent effort), NHLBI, HL 44612-15, 2000-2005

Representative publications

  • Wilcox DA, White II GC. Gene Therapy for Platelet Disorders. Platelets. Michelson AD (ed.), Academic Press, San Diego. 2002; 61:927-37
  • Wilcox DA, White II GC. Gene Therapy for Platelet Disorders: Studies with Glanzmann's Thrombasthenia. Journal of Thrombosis and Haemostasis. 2003; 1:2300-2311
  • Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White II GC, Montgomery RR. Induction of Megakaryocytes to Synthesize and Store a Releasable Pool of Human Factor VIII, Focus Article. Journal of Thrombosis and Haemostasis. 2003; 1:2477-89
  • Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop Jr CD. Correction of a Large Animal Model of Type I Glanzmann's Thrombasthenia by Nonmyeloablative Marrow Transplantation. Experimental Hematology. 2003; 31:1357-62
  • Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR. Targeting Platelet GPIbá Transgene Expression to Human Megakaryocytes and Forming a Complete Complex with Endogenous GPIbâ and GPIX. Journal of Thrombosis and Haemostasis. 2004; 2:1989-1997
  • Fang J, Hodivala-Dilke KM, Johnson BD, Hynes RO, White II GC, Wilcox DA. Therapeutic Expression of the Platelet-specific Integrin, aIIbb3, in a Murine Model for Glanzmann Thrombasthenia. 2004