John M Routes, MD

Medical director, Allergy/Clinical Immunology, Children's Hospital of Wisconsin
Professor and chief, the Medical College of Wisconsin

Office locations

8915 W. Connell Ct.
Milwaukee, WI 53226
(414) 266-6840 (office)
(414) 266-6450 (clinic/appointments)


Dr. John Routes serves as the co-Director of the Clinical and Translational Science Institute of Southeast Wisconsin and the Director of the Jeffrey Model Foundation (JMF) Research and Diagnostic Center for Primary Immunodeficiencies at the Medical College of Wisconsin. Dr. Routes received his undergraduate degree at Indiana University, Bloomington (Phi Beta Kappa), Medical Degree at Indiana University School of Medicine, Indianapolis (Alpha Omega Alpha), his training in Internal Medicine at the University of Utah and Fellowship training in Allergy and Clinical Immunology and Infectious Diseases at the University of Colorado and National Jewish Health, where he was a faculty member until 2006 when he assumed his present position at the Medical College. Dr. Routes has served on numerous NIH study sections, including Chairman of the “Opportunities for Collaborative Research at the NIH Clinical Center” study section and is currently a member of the “Investigations in Primary Immunodeficiency” study section and is a voting member of the FDA Immunology Devices and Medical Devices Panels. In 2008, Dr. Routes was the Principal Investigator for the pilot study in Wisconsin that instituted the first statewide newborn screening program for severe combined immunodeficiency. In addition to a research interest in developing high-throughput screening assays adaptable for population-based newborn screening for primary immunodeficiencies, Dr. Routes has a longstanding interest in defining the etiology and optimizing the treatment of the granulomatous and lymphocytic interstitial lung (GLILD), a major complication in patients with common variable immunodeficiency (CVID). 

Allergy and Immunology, Internal Medicine - General
Areas of interest
  • Allergy/immunology
  • Common variable immune deficiency (CVID)
  • Immune dysregulation
  • Immunodeficiency
  • Immunology mediated lung diseases
  • Recurrent infections
  • Severe combined immune deficiency (SCID)
  • Sinusitis

Education and awards

  • 1981, Indiana University School of Medicine, MD
  • 1984, University of Utah (Salt Lake City, UT) - Internal Medicine
  • 1989, National Jewish Medical and Research Center (Denver, CO) - Allergy/Immunology
  • 1990, University of Colorado (Denver, CO) - Infectious Disease
  • Best Doctors in America
  • 2008 Health Care Hero Award, Milwaukee Small Business Times
  • 2008-present Immune Deficiency Foundation, LeBien Visiting Professor
  • 2009 Pioneer in Newborn Screening-Dream Maker Award, Jeffrey Modell Foundation 
  • 2011-present U.S. News & World Report, Top Doctors 
  • 2013-2014 President, Clinical Immunology Society

Research and publications