Mitchell H Grayson, MD

CHILDREN'S HOSPITAL OF WISCONSIN SINCE 2008
Associate professor, the Medical College of Wisconsin

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226
(877) 607-5280 (appointment)
(414) 266-6450 (clinic)

Overview

Best Doctors 2013Dr. Grayson graduated with a B.A. from Knox College in Galesburg, IL before attending the University of Chicago, Pritzker School of Medicine, from which he received his medical degree in 1993.  After completing an internal medicine residency at the Hospital of the University of Pennsylvania, he undertook his allergy/immunology fellowship at Johns Hopkins University.  Upon completion of his fellowship in 1998 he joined the faculty of Washington Univ. School of Medicine.  Dr. Grayson was a faculty member in the division of Allergy and Immunology at Washington University until 2008, when he left St. Louis to take a position as an Associate Professor at the Medical College of Wisconsin (Milwaukee, WI).  Dr. Grayson is currently an Associate Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics at the Medical College of Wisconsin.

In terms of community involvement, while in St. Louis, Dr. Grayson was a member of the St. Louis Asthma Consortium, having served as Secretary/Treasurer for the group, as well as Chair of the Best Practices Committee.  He has served on the Board of Directors of the St. Louis Chapter of the Asthma and Allergy Foundation of America, and was a member of the Asthma Education Committee and Community Initiatives Committee of the American Lung Association of Eastern Missouri.  Dr. Grayson now serves as Director of Fight Asthma Milwaukee (FAM) Allies, and is on the Board of Directors of the national Asthma and Allergy Foundation of America.  He is also co-director of the Infection, Inflammation and Immunity research unit of the Children’s Research Institute of the Children’s Hospital of Wisconsin.

Dr. Grayson has been the recipient of several National Institutes of Health research grants, and oversees an active laboratory studying the role that viral infections play in the development of allergic disease.  He has published over 45 peer-reviewed articles, and has trained 11 post-doctoral or clinical research fellows.  He is a board certified diplomate of the American Board of Allergy and Immunology, and is an active fellow of the American Academy of Allergy, Asthma, and Immunology, as well as the American College of Allergy, Asthma, and Immunology.  He serves as an Associate Editor of the Annals of Allergy, Asthma, and Immunology, and is an Associate Editor of the Journal of Immunology.  He recently completed a term on the editorial board of the Journal of Allergy and Clinical Immunology.  Dr. Grayson has served on numerous study sections for the National Institutes of Health, is a member of the Collegium Internationale Allergologicum, the allergy research honorary society, and has just been elected to the American Society for Clinical Investigation.  Dr. Grayson has also been named a “Best Doctor in America”, as well as being selected as one of “America’s Top Physicians” and a “Top Allergist/Immunologist”.  His clinical interests are primarily asthma, allergic rhinitis, food allergy, and anaphylaxis.

Certifications
Allergy and Immunology
Areas of Interest
  • Allergy/immunology
  • Asthma
  • Allergy
  • Allergic rhinitis
  • Food allergy
  • Hives
  • Atopic dermatitis
  • Hereditary angioedema
  • Anaphylaxis
  • Hay fever
  • Immunodeficiency
  • Reactive airway disease

Education & Awards

Education
  • 1993, University of Chicago-Pritzker School of Medicine, MD
Residency
  • 1995, University of Pennsylvania (Philadelphia, PA)
Fellowship
  • 1998, Johns Hopkins University School of Medicine
Awards
  • Named one of America’s Top Physicians in Allergy and Immunology by Consumers’ Research Council of America (2011)
  • Fellow, American Academy of Allergy, Asthma, and Immunology
  • Fellow, American College of Allergy, Asthma, and Immunology
  • Elected member of the Collegium Internationale Allergologicum
  • Elected member of the American Society for Clinical Investigation

Research & Publications

Research

Allergies are a major health burden and the number of people afflicted is increasing rapidly in the westernized world.  It is not known why these diseases are increasing, but it has been documented that severe viral infections early in life greatly increase a child’s risk of developing asthma and allergies. To understand the mechanisms behind how a viral infection can lead to allergic disease, we have been using a mouse model where the mice develop allergies and asthma after a single respiratory infection with a mouse-specific virus.

Our studies are now focused on trying to understand the specific cells that are involved in this response, and seeing how they translate the viral infection into allergic diseases.  Additional work has begun to determine whether the pathways identified in mice are also operative in humans.  Our preliminary data suggest that at least portions of our model are indeed relevant to human disease.

While these initial studies were focused on the lungs and respiratory infections, we are now exploring whether similar events could occur in the intestinal tract.  If successful, these studies may outline a novel mechanism through which children could develop food allergies.  We hope that these studies (and the lung specific studies mentioned above) will ultimately lead to the development of therapeutic interventions to stop or prevent the development of allergies throughout childhood.  As a side benefit of these studies, we also hope to better understand the immune system response to viral infections in both the lungs and the intestinal tract.

  • Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
  • Cutting edge: CD49d+ neutrophils induce FceRI expression on lung dendritic cells in a mouse model of postviral asthma.
  • Expression of High-Affinity IgE Receptor on Human Peripheral Blood Dendritic Cells in Children.
  • Rhinovirus specific IgE can be detected in human sera.
  • CD49d-expressing neutrophils differentiate atopic from nonatopic individuals.

View all publications from Mitchell H. Grayson, MD.