Funding and publications

Current funding

  • 1R01HL102745-01 (Ramchandran, R.) 2011-2015 - NIH/NHLBI. Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebrates - Role: PI
  • 1R01HL112639-01 (Ramchandran, R.) 2012-2016 - NIH/NHLBI. Targeting DUSP-5 to Treat Vascular Anomalies - Role: PI
  • VITA (Ramchandran, R.) 2013-2016 - NIH/NHLBI. Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program - Role: PI
  • 1R01HL111582-01 (Wodnicka, M. and Ramchandran, R.) 2012-2017 - NIH/NHLBI. Rap1 in VEGF signaling in endothelial cells - Role: Co-I
  • 1R01HL120585 (Mukherjee, P. and Ramchandran, R.) 2013-2018 - NIH/NHLBI. Cystathionine beta synthase (CBS) and angiogenesis - Role: Co-I
  • 1R01HL108938-01 (Miao, R. and Ramchandran, R.) – 2011-2016 - NIH/NHLBI. Role of NgBR - Role: Co-I
  • 2R01HL033833-29 (Harder, D and Ramchandran, R.) 2014-2019 - NIH/NHLBI. Astrocyte Secretome: Ability to Modify Phenotype and Genotype of Cells within CNS - Role: Co-I

Publications (2010-present)`

  • Jia Y, Wu S-L, Isenberg JS, Sipes JM, Field L, Zeng B, Bandle RW, Ramchandran R, Karger BL and Roberts DD. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with the actin cytoskeleton. Cell Stress Chaperones 2010 Mar;15(2):165-81; PMCID: PMC2866983.
  • Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh N, Chun C, Samant G, Zhao B, Garnaas M, Horswill M, Stanhope S, North P, Miao R, Wilkinson G, Affolter M and Ramchandran R. A noncoding antisense RNA at the tie-1 locus regulates tie-1 transcript levels function in vivo. Blood 2010 Jan 7;115(1):133-9; PMCID: PMC2803688.
  • Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant G, Horswill M, Chun C, Mukhopadhyay D, Ramchandran R and Wilkinson G. Ecscr promotes angioblast migration during vasculogenesis and enhances kdr sensitivity. Blood 2010 Jun 3;115(22):4614-22; PMCID: PMC2881497. **Inside Blood commentary: EC-specific chemotaxis receptor: a double-edged sword, p. 4614.
  • Zhao B, Chun C, Liu Z, Horswill M, Pramanik K, Wilkinson G, Ramchandran R and Miao R. Nogo-B receptor is essential for angiogenesis in vivo via Akt pathway. Blood 2010. Dec 9;116(24):5423-33; PMCID: PMC3012551.
  • Chun CZ, Remadevi I, Schupp M, Samant GV, Pramanik K, Wilkinson GA and Ramchandran R. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. PLoS One 2011 Feb 25;6(2):e14732; PMCID: PMC3045372.
  • Lakshmikanthan S, Sobczak M, Chun CZ, Henschel A, Dargatz J, Ramchandran R and Chrzanowska-Wodnicka M. Rap1b regulates angiogenesis by an endothelial cell-autonomous mechanism involving integrin αvβ3-dependent VEGFR2 activation. Blood 2011 Aug 18;118(7):2015-26. Epub 2011 Jun 2; PMCID: PMC3158727. (with “Inside Blood” commentary)
  • Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P and Ramchandran R. Sox factors transcriptionally regulate robo4 expression in the developing vasculature in zebrafish. J Biol Chem. 2011 Sep 2;286(35):30740-7. Epub 2011 Jul 5; PMCID: PMC3162435.
  • Patra C, Kim J, Pramanik K, d’Uscio LV, Patra S, Ramchandran R, Strano M and Mukhopadhyay D. Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett. 2011 Nov 9;11(11):4932-8. Epub 2011 Oct 10; PMCID: PMC3212653.
  • Wickramasekera N, Gebremedhin D, Carver K, Vakeel P, Ramchandran R, Schuett A and Harder D. Role of dual-specificity protein phosphatase-5 (DUSP-5) in modulating myogenic response in rat cerebral arteries. Paper #: JAPPL-01026-2011R3. J Appl Physiol. 2013 Jan 15;114(2):252-61.  PMCID: PMC3544499.
  • Kilari S, Remadevi I, Zhao B, Miao Q, Ramchandran R, North PE, Rahimi N and Wilkinson GA. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J Biol Chem. 2013 Apr 12;288(15):10265-74. PMCID: PMC3624410.
  • Span EA, Goodsell DS, Ramchandran R, Franzen M, Hemran T and Sem DS. Protein structure in context: The molecular landscape of angiogenesis. Biochem Mol Biol Educ. 2013 Jul-Aug;41(4):213-23 PMCID:  PMC4074543.
  • Leigh NR, Schupp MO, Li K, Vakeel P, Gastonguay A, Wang, L, Chun CZ, Wilkinson GA and Ramchandran R. Mmp17b and its putative substrate Reck are essential for neural crest migration in vivo. PLoS ONE 2013 8(10):e76484. Doi:10.1371/journal.pone.0076484.  PMCID:  PMC3788140.
  • Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR and Ramchandran R. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE 2013 Dec 4;8(12):e80933. Doi: 10.1371/journal.pone.0080933. PMCID: PMC3851470.
  • Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP and Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014 Mar 15;23(60:1644-55. Doi: 10.1093/hmg/ddt556. PMCID: PMC 3929098.
  • Sampath V and Ramchandran R.  (2014) Translational Research – It Takes Two to Tango! MOJ Cell Sci Report 1(1): 00003.
  • Schupp MO, Waas M, Chun CZ and Ramchandran R.  Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development.  Dev Biol.  2014 Jun 28. Pii: S0012-1606(14)00315-7. PMCID:  PMC4137469.
  • Rajasimha HK, Prasannakumar BS, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K, Verma IC. “Organization for Rare Diseases India (ORDI) – Addressing the Challenges and Opportunities for Indian Rare Disease Patients.” Manuscript Number:  Genetics-D-14-00017R1. PMID: 25579084.
  • Cossette SM, Gastonguay A, Bao X, Lerch-Gaggl A, Zhong, L, Harmann LM, Koceja C, Miao, RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP and Ramchandran R.  Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.  Biol Open 2014 Dec 12. Pii: BIO20149811.  PMCID:  PMC4295165.
  • Nayak J, Gastonguay A, Talipov MR, Padmanabhan P, Span E, Kutty R, Jensen D, Pokkuluri P, Sem DS, Rathore R and Ramchandran R.  Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins.  BMC Biochemistry 2014 Dec 18;15(1):27. PMCID:  PMC4299175.
  • Menden H, Welak S, Cossette S, Ramchandran R and Sampath V. LPS-mediated Angiopoietin-2 dependent autocrine angiogenesis is regulated by Nox2 in human pulmonary microvascular endothelial cells. J. Biol. Chem. 2015 Feb 27;290(9): 5449-61. PMCID:  PMC4342461.
  • Sampath V, Menden H, Helbling D, Gastonguay A, Li K, Tschannen MR, Worthy EA, Ramchandran R and Dimmock DP.  SIGIRR mutations in a premature infant with lethal neonatal necrotizing enterocolitis.  Pediatrics 2015 In Press.
  • Li K, Chowdhury T, Vakeel P, Koceja C, Sampath and Ramchandran R.  Delta-like4 mRNA is regulated by adjacent natural antisense transcripts. Vascular Cell 2015 In press.
  • Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun CZ, Ramchandran R, Ekker SC and Mukhopadhyay D.  RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.  Journal of Cell Sci. 2015 In Press.

* Denotes Joint First-Author