Laboratory of Molecular Immunology and Immunotherapy
Blood Research Institute, Blood Center of Wisconsin
Instructor of Pediatrics, Medical College of Wisconsin - Fellow of Pediatric Hematology/Oncology/BMT
Kindlin-3 is a focal adhesion protein expressed in hematopoietic cells regulating integrins. Our lab has previously described a role for ADAP in the cytokine specific NK cell response without alterations in cytotoxicity. This has application for limiting inflammatory response but preserved targeted killing, in particular malignancy surveillance. For potential ADAP modulation its binding and functional partners must be further elucidated. Kindlin-3 is known to interact with ADAP in the function of integrins. Utilizing a floxed Kindlin-3 model I will evaluate the effect Kindlin-3 loss has on the functional development of NK cells including cytotoxic and cytokine release capabilities.