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Robert H Lane
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Robert H Lane, MD

CHILDREN'S HOSPITAL OF WISCONSIN SINCE 2013

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    Best Doctors 2013Dr. Lane’s research focuses upon how perinatal events lead to adult disease. His expertise is how these perinatal events impact the epigenetic characteristics and subsequent expression of specific genes. In 2003, we published our first manuscript on how intrauterine growth restriction (IUGR) affects renal p53 DNA methylation. Our subsequent manuscripts were among the first to demonstrate pronounced gender specificity in the perinatal epigenetic response. Moreover, our publications introduced the concept that many key epigenetic responses to the perinatal environment occur outside the promoter and may even include the 3’ UTR. This concept is important because it mechanistically allows for an adaptive moderate response to an adverse perinatal environment, as opposed to a more severe response resulting from epigenetically modifying a dominant promoter, which typically occurs within the context of developmental ontogeny and tissue specificity. We included this latter finding and concept in our 2009 FASEB publication “Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene”. Our work was been coined the new “epigenetics” by Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. We are not a laboratory that has recently jumped on the epigenetic bandwagon by learning a new set of techniques. We are a laboratory that is fully committed to understanding the 1) mechanisms through which early life events affect epigenetic markers and 2) how the new epigenetic marks determine latter life phenotype.

    Certifications

    • Neonatal-Perinatal Medicine

    Areas of interest

    • Neonatology
    • Fetal and neonatal determinants of adult disease
    • Epigenetics
    • Molecular genetics