Yi-Guang Chen, PhD

Investigator, Children's Research Institute
Assistant professor, Pediatrics, The Medical College of Wisconsin

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226
(414) 456-7583
(414) 456-6516

Overview

Division
  • Endocrinology/Diabetes

Research interests

  • Diabetes/obesity

Study interests

  • Immunogenetics, type 1 diabetes

Education

  • Doctorate, University of Rochester, Rochester, NY, 2002

Education & Awards

Awards
  • Graduate Fellowship, University of Rochester, NY, 2002
  • Postdoctoral Fellowship, Juvenile Diabetes Research Foundation International, 2005
  • Travel Award, Immunology of Diabetes Society 8th meeting (Japan), 2005
  • NIH K99 Pathway to Independence Award, 2010, NIH R00 Pathway to Independence Award, 2010-2013

Research

Selected recent publications
  • Genetic Control of Diabetogenic CD4 T Cells in NOD Mice (1-10-BS-26), American Diabetes Association, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (4R00DK077443-03), National Institutes of Health (NIH), National Instituite of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (24-2007-374), Juvenile Diabetes Research Foundation International, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (5K99DKO77443-02) National Institutes of Health (NIH), National Institute of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice - ARRA Administrative Supplement, (3K99DK077443-02S1Z), National Institutes of Health (NIH), National Institute of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.

Representative publications/presentations

  • Y.-G. Chen, C.-M. Choisy-Rossi, T.M. Holl, H.D. Chapman, G.S. Besra, S.A. Porcelli, D.J. Shaffer, D. Roopenian, S. B. Wilson, and D.V. Serreze. Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J. Immunol. 2005; 174: 1196-1204.
  • Y.-G. Chen, F. Scheuplein, M.A. Osborne, S.-W. Tsaih, H.D. Chapman, D.V. Serreze. The Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in non-obese diabetic (NOD) mice. Diabetes 2008; 57:3273-3280.
  • Y.-G. Chen*, S.W. Tsaih, D.V. Serreze. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun 2012; 13:164-174 . *corresponding author
  • S.-W. Tsaih, S. Khaja, A.E. Ciecko, E. MacKinney, and Y.-G. Chen. Genetic control of murine invariant natural killer T-cells maps to multiple type 1 diabetes regions. Genes Immun 2013; 14: 380-6.
  • Y.-G. Chen*, M. Forsberg, S. Khaja, A.E. Ciecko, M.J. Hessner, and A.M. Geurts. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes 2014; 63: 68-74. *corresponding author

View all of the publications by Yi-Guang Chen, PhD.