Ramani Ramchandran, PhD

Investigator, Children's Research Institute
Professor, Department of Pediatrics
Professor, Developmental Vascular Biology program and Zebrafish Drug Screening Core, The Medical College of Wisconsin
Patrick J. and Margaret G. McMahon Professor of Obstetrics and Gynecology
Vice Chair for Research Obstetrics and Gynecology

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226
(414) 955-2387
(414) 955-6325

Overview

Division
  • Pediatrics
Research interests
  • Cell and developmental biology

Study interests

  • Angioblast development in vertebrates
  • Role of axon guidance genes in vascular development
  • Translational disease models in fish

Education

  • Doctorate, Medical College of Georgia, Augusta, 1997
  • Post-doctoral fellowship, Harvard Medical School, Boston, 1997-2002

Education & Awards

Awards
  • Batliboi Scholarship Award (bachelor's degree), 1990
  • Batliboi Scholarship Award (master's degree), 1991
  • Tata Memorial Scholarship Award, 1992; Graduate Research Assistantship Award, 1992
  • Third place, Sigma XI, 1997; Listed in "Who's Who Among Students in American Universities and Colleges," 1997
  • Special Recognition Award from Student Government Association, 1997; Ruth L. Kirchstein National Research Service Award, 2001
  • National Cancer Institute Scholar Award, 2002; Nominated for Outstanding Mentor Award, NCI, National Institutes of Health, 2004
  • Listed in Madison, Wis., "Who's Who of Business Leaders and Professionals," 2006; Cash Performance Award, NIH, 2006
  • Two Year Complimentary Membership to American Association of Anatomist (successful nomination of a Bensley Award Recipient), 2007
  • The Donald & Judith Alstadt Charitable Research Foundation Award, 2010

Research & Publications

Research
  • 1R01HL090712-01A2 (Ramchandran, R.) 2009-2013 "Roundabout4 signaling in endothelial cells" Role: PI
  • 1R01HL102745-01 (Ramchandran, R.) 2011-2015 "Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebrates" Role: PI
  • 1R01HL112639-01 (Ramchandran, R.) 2011-2016 "Targeting DUSP-5 to Treat Vascular Anomalies" Role: PI
  • 1R01HL108938-01 (Miao, R. and Ramchandran, R.) 2011-2016 "Role of NgBR" Role: Co-I
  • HL007792 (Harder, D.) 2009-2014 NIH T32 Training Program "Hypertension and Vascular Biology Training Grant" Role: Mentor
  • 1R01HL111582-01 (Wodnicka, M. and Ramchandran, R.) 2012-2017 "Rap1 in VEGF signaling in endothelial cells" Role: Co-I
  • 2R44HL097465-02 (Ferrante, A. and Ramchandran, R.) 2012-2014 "Fully automated angiogenesis drug discovery assay in zebrafish – Phase II" Role: Co-I
  • NA (Ramchandran, R. and Duffy, K.) 2012-2013 "Molecular crosstalk and matrix metalloproteinases in generalized lymphatic anomaly (GLA) and gorham-stout syndrome (GSS) patients" Role: PI

Representative publications/presentations

  • Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE and Ramchandran R. Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood 2009, 113 (5):1184-1191; PMC2635084. **Inside Blood commentary: The hunting of the Snrk, p. 983.
  • Chun CZ, Kaur S, Samant GV, Wang L, Pramanik K, Garnaas M, Li K, Field L, Mukhopadhyay D and Ramchandran R. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Blood 2009, 113 (5):1192-1199; PMC2635085. **Inside Blood commentary: The hunting of the Snrk, p. 983.
  • Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P and Ramchandran R. Sox factors transcriptionally regulate robo4 expression in the developing vasculature in zebrafish. J Biol Chem. [REF] 2011 Sep 2;286(35):30740-7. Epub 2011 Jul 5; PMC3162435.
  • Leigh NR, Schupp MO, Li K, Vakeel P, Gastonguay A, Wang, L, Chun CZ, Wilkinson GA and Ramchandran R. Mmp17b and its putative substrate Reck are essential for neural crest migration in vivo. PLoS ONE 2013 8(10):e76484. Doi:10.1371/journal.pone.0076484.
  • Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR and Ramchandran R. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE 2013 Dec 4;8(12):e80933. Doi: 10.1371/journal.pone.0080933. PMCID: PMC3851470.
View all of the publications by Ramani Ramchandran, PhD.