Nancy J Wandersee, PhD

Investigator, Children's Research Institute
Assistant professor, Medical College of Wisconsin

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 937-3815
(414) 937-6811 (fax)

Overview

Division

  • Hematology, Oncology and Transplant

Research center/program

  • Bleeding disorders research

Research interests

  • Bleeding and blood disorders
  • Sickle cell anemia
  • Cell and developmental biology
  • Disease pathology

Study interests

  • Red blood cell membrane/membrane skeleton
  • Hereditary spherocytosis and elliptocytosis
  • Sickle cell disease
  • Hemolysis and vascular injury
  • Mouse models
  • Pathophysiology of stroke, thrombosis and vascular dysfunction

Education

  • Doctorate, Genetics, University of Iowa, Iowa City, 1995
  • Post-doctoral fellowship, Red Blood Cell Research, The Jackson Laboratory, Bar Harbor, Maine, 1995-2001

Education & Awards

Awards
  • Phi Kappa Phi National Honor Society and Gamma Sigma Epsilon Chemistry Honor Society, 1986
  • Outstanding Undergraduate Research Award, Sigma Xi Scientific Research Society, 1986
  • Member Sigma Xi Scientific Research Society 1986–present
  • Member American Association for the Advancement of Science, 1997–present
  • Member American Society of Hematology 1998–present

Research & Publications

Research
  • Nociceptive Mechanisms Underlying Sickle Cell Pain, National Institutes of Health (NIH) (NHLBI/NINDS, co-investigator
  • Research Project Cooperative (U54 Grant): Midwest Basic and Translational Research Parogram (BTRP), NIH (NHBI), Core Leader (Animal Core), principal investigator (Blood Center subcontract), co-investigator (Project 4: Cell Free Hemoglobin, Lipid Oxidation, and Nitric Oxide in Sickle Cell Disease)
  • Mechanisms of Vascular Injury in Murine Hemolytic Anemia, American Heart Association, National Center Scientist Development Grant, principal investigator

Representative publications

  • Wandersee NJ, Roesch AN, Hamblen NR, de Moes J, van der Valk MA, Bronson RT, Gimm JA, Mohandas N, Demant P, Barker JE. Defective Spectrin Integrity and Neonatal Thrombosis in the First Mouse Model for Severe Hereditary Elliptocytosis. Blood. 2001; 97:543-550
  • Wandersee NJ, Olson SC, Holzhauer SL, Hoffmann RG, Barker JE, Hillery CA. Increased Erythrocyte Adhesion in Mice and Humans with Hereditary Spherocytosis and Hereditary Elliptocytosis. Blood. 2004; 103:710-716
  • Wandersee NJ, Punzalan RC, Rettig MP, Kennedy MD, Pajewski NM, Sabina RL, Scott JP, Low PS, Hillery CA. Erythrocyte Adhesion is Modified by Alterations in Cellular Tonicity and Volume. Br. J. Haem. 2005; 131:366-377
  • Frei AC, Guo Y, Jones DW, Pritchard KA, Jr., Fagan KA, Hogg N, Wandersee NJ. Vascular Dysfunction in a Murine Model of Severe Hemolysis. Blood. 2008; 112:398-405. PMCID: PMC2442729
  • Campanella ME, Chishti A, Wandersee MJ, Peters LL, Narla M, Gilligan D, Low PS. Characterization of Glycolytic Enzyme Interactions with Murine Erythrocyte Membranes in Wild Type and Membrane Protein Knockout Mice. Blood. 2008; 112:3900-3906. PMCID: PMC2572807
  • Sabina RL, Wandersee MJ, Hillery CA. Ca2+-CaM Activation of AMP Deaminase Contributes to Adenine Nucleotide Dysregulation in Human Sickle Erythrocytes. Br. J. Haem. 2009; 144:434-445. PMCID: PMC2701153