Kirkwood A. Pritchard Jr., PhD

Investigator, Children's Hospital of Wisconsin's Research Institute
Professor, Surgery, Pharmacology and Toxicology, vice chair, Research Surgery, chairman, Research Affairs Committee, director, Translational Vascular Biology Program, Medical College of Wisconsin

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 955-5615
(414) 955-6473 (fax)

Overview

Division

  • Surgery

Research interests

  • Cancer
  • Disease pathology
  • Gastrointestinal diseases
  • Heart disease
  • Respiratory diseases
  • Asthma
  • Rheumatological disorders
  • Surgery

Education

  • Doctorate, Ohio State University, Columbus, 1983
  • Postdoctoral fellow, Albert Einstein College of Medicine, Bronx, N.Y., 1985

Certifications

  • American Board of Clinical Chemistry, September 1999, board certified

Research & Publications

Research
  • National Institutes of Health (NIH)/National Heart, Lung and Blood Institute (NHLBI), HDL Dysfunction and Vascular Inflammation, principal investigator, 2006-2012
  • National Institutes of Health (NIH)/National Heart, Lung and Blood Institute (NHLBI), Asthma Increases Vaso-occlusion in Sickle Cell Disease, co-investigator, 2010-2014
  • National Institutes of Health (NIH)/National Heart, Lung and Blood Institute (NHLBI), Novel Peptide MPO Inhibitors for Treating Atherosclerosis, principal investigator, 2011-2012
  • Department of Defense, Reduction of Vibration Induced Fatigue or Injuries by Pre-Conditioning with D-4F, co-investigator, 2011-2014

Representative publications

  • Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard Jr., KA. Genetic Deletion of Apolipoprotein A-1 Increases Airway Hyperresponsiveness, Inflammation, and Collagen Deposition in the Lung. J Lipid Res. 2010; Sep; 51(9):2560-70. PMCID in process
  • Nandedkar S, Feroah T, Hutchins W, Weihrauch D, Konduri K, Wang J, Strunk R, DeBaun M, Hillery C, Pritchard Jr., KA. Histopathology of Experimentally-induced Asthma in a Murine Model of Sickle Cell Disease. Blood. 2008; 1126(6):2529-2538. PMCID: PMC2532817
  • Xu H, Shi Y, Wang J, Jones D, Weihrauch D, Ying R, Wakim B, Pritchard KA, Jr. A Heat Shock Protein 90 Binding Domain in Endothelial Nitric-oxide Synthase Influences Enzyme Function. J Biol Chem. 2007; 282:37567-37574Weihrauch D, Xu H, Shi Y, Wang J. Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard Jr, KA. Effects of D-4F on Vasodilation, Oxidative Stress, Angiostatin, Myocardial Inflammation, and Angiogenic Potential in Tight-Skin Mice. Am J Physiol Heart Circ Physiol. 2007; 293(3):H1432-41
  • Ou J, Wang J, Xu H, Ou Z, Sorci-Thomas M, Jones DW, Signorino P, Densmore JC, Kaul S, Oldham KT, Pritchard JR. KA. Effects of D-45 on Vasodilation and Vessel Wall Thickness in Hypercholesterolemic LDL Receptor Null and LDL Receptor/ApoA-1 Double Knockout Mice on Western Diet. Circ Res. 2005; 97:1190-97
  • Pritchard Jr. KA, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, Hillery CA. Hypoxia-induced Acute Lung Injury in Murine Models of Sickle cell Disease. Am J Physiol Lung Cell Mol Physiol. 2004; 286:L705-14