Katherine Shim, PhD

Investigator, Children's Hospital of Wisconsin's Research Institute
Assistant professor, Pediatrics, Cell Biology, Neurobiology and Anatomy, and Otolaryngology and Communications Sciences, Medical College of Wisconsin

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 955-2444
(414) 955-6329 (fax)



  • Genetics

Research center/program

  • Regenerative Medicine and Developmental Biology

Research interests

  • Cell and developmental biology
  • Ear diseases, deafness
  • Environmental health
  • Genetic diseases/genomics

Study interests

  • Hearing and balance
  • Neurodegeneration
  • Mouse genetics
  • Birth defects


  • Doctorate, Stanford University, Palo Alto, CA, 2001
  • Post-doctoral fellowship, University of California, San Francisco, 2001-2007

Research & Publications

  • Genetic Analysis of the Induction and Morphogenesis of the Inner Ear, National Institutes of Health, principal investigator
  • Genetic Analysis of Degeneration of the Olfactory Epithelium, NIEHS Children's Environmental Health Sciences Core Center, principal investigator

Representative publications

  • Shim K, Blake KJ, Jack J, Krasnow MA. The Drosophila Ribbon Gene Encodes a Nuclear BTB Domain Protein that Promotes Epithelial Migration and Morphogenesis. Development. 2001; 128:4923-4933
  • Shim K, Minowada G, Coling DE, Martin GR. Sprouty2, A Mouse Deafness Gene, Regulates Cell Fate Decisions in the Auditory Sensory Epithelium by Antagonizing FGF Signaling. Developmental Cell. 2005; 8:553-564
  • Shim K. The Auditory Sensory Epithelium: The Instrument of Sound Perception. International Journal of Biochemistry and Cell Biology. 2006; 38:1827-33
  • Mahoney Rogers AA, Zhang J, Shim K. Sprouty1 and Sprouty2 limit both the Size of the Otic Placode and Hindbrain Wnt8a by Antagonizing FGF Signaling. Developmental Biology. 2011; 94-104
  • Shim K. Vibratome Sectioning for Enhanced Preservation of the Cytoarchitecture of the Mammalian Organ of Corti. Journal of Visualized Experiments. 2011; 52