John A. Corbett, PhD

Chairman and professor, Biochemistry, Medical College of Wisconsin



  • Biochemistry

Study interests

  • Function and survival of Pancreatic beta cells in Type 1 and 2 diabetes


  • Doctorate, Utah State University, Logan, UT, 1990

Medical College of Wisconsin
Department of Biochemistry
8701 Watertown Plank Road
Milwaukee, WI 53226
Phone: (414) 955-8768
Fax: (414) 955-6510

Education & Awards

  • Greenwood Award (top Biochemistry Graduate Student, Utah State University), 1990
  • Individual National Research Service Award (NIH Postdoctoral Fellowship), 1994
  • Juvenile Diabetes Foundation Career Development Award, 1999
  • Scientific Advisory Board: International Conference on Nitric Oxide, 2000, 2002, 2004
  • Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research, University of Alabama at Birmingham, 2007

Research & Publications

  • Biochemical Mechanism of ®-cell Destruction, National Institutes of Health, NIH, National Institute of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator
  • Mechanisms of Viral-induced ®-cell Damage, National Institutes of Health, NIH, National Institute of Allergy and Infectious Diseases, NIAID, principal investigator

Representative publications

  • Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA. 2011. IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol., 31:4286-97 PMID: 21896783, PMCID: 3209336
  • Hughes, KJ, Meares, G, Hansen, PA, and Corbett, JA. 2011. FoxO1 and SIRT1 regulate β-cell responses to nitric oxide. J. Biol. Chem. 286: 8338–8348, PMID: 21196578, PMCID: 3048718
  • Christsmann, B, Moran, JM, Buller, RM, and Corbett, JA. 2011. CCR5 a novel cell surface signaling receptor for EMCV and dsRNA. Am. J. Pathol. 179:2941-2951 PMID: 22001348, PMCID: 3260827
  • Baldwin, AC, Green CD, Olson, LK, Moxley, MA, and Corbett, JA. 2012. A role for aberrant protein palmitoylation in FFA-induced ER stress and beta cell death. Am. J. Physiol Endocrinol Met. E1390-8. PMID:22436701, PMCID: 3378068
  • Broniowska, KA, Mathews, CE and Corbett, JA. 2013. β-cells do not generate peroxynitrite in response to cytokine treatment. J. Biol. Chem. 288:36567-36578

See a complete list of publications by Dr. John A. Corbett