Hau Xu, PhD

Investigator, Children's Hospital of Wisconsin's Research Institute
Assistant professor, Pediatric Surgery, The Medical College of Wisconsin

Office Locations

8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 955-2432
(414) 955-6473 (fax)

Overview

Division

  • Surgery

Research center/program

  • Developmental Vascular Biology Program

Research interests

  • Bleeding and blood disorders
  • Cancer
  • Dermatologic diseases
  • Diabetes/obesity
  • Heart disease

Study interests

  • Oxidative stress
  • eNOS
  • Endothelial dysfunction
  • Extracellular matrix
  • Fibronectin
  • Oxidative modification
  • Inflammation
  • Angiogenesis
  • Senescence

Education

  • Doctorate, University of Tromso, Norway, 2003

Education & Awards

Awards
  • AHA Midwest Affiliate Postdoctoral Fellowship award, 2005-2006

Research & Publications

Research

National Institutes of Health, The Role of Oxidatively Modified Fibronectin in Atherosclerosis, principal investigator, pending

Representative publications

  • Xu H and Pritchard KA Jr. Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-dependent Nitric Oxide Production, not Uncoupled eNOS Activity. Arterioscler Thrombosis Vascular Biology. 2008; 28:1580-1581
  • Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard Jr KA and Shi Y. Identification of Proteins Interacting with GTP Cyclohydrolase 1. Biochemistry Biophysics Research Community. 2009; 385:143-147. PMCID: 2737525
  • Whitehouse JS, XU H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA, Oldham KT, Gourlay DM. Mesenteric Nitric Oxide and Superoxide Production in Experimental Necrotizing Enterocolitis. Journal of Surgical Research. 2010; 161(1):1-8. PMCID in process
  • Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, and Pritchard KA. Genetic Deletion of Apolipoprotein A-1 Increases Airway Hyperresponsiveness, Inflammation and Collagen Deposition in the Lung. Journal of Lipid Research. 2010; 51(9):2560-70. PMCID in process
  • Nandedkar SD, Weihrauch D, XU H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Prichard KA Jr. D-4F, an ApoA-1 Mimetic, decreases Airway Hyperresponsiveness, Inflammation and Oxidative Stress in a Murine Model of Asthma. Journal of Lipid Research. 2011; 52(3):499-508. PMCID in process
  • Teng R-J, Du J-H, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA, Jr. and Konduri GG. Sepiapterin Improves Angiogenesis of Pulmonary Artery Endothelial Cells with Inutero Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Am J Physiol Lung Cell Mol Physiol. 2011; accepted. PMCID in process