Robert H Lane, MD

CHILDREN'S HOSPITAL OF WISCONSIN SINCE 2013
Pediatrician-in-Chief, Children's Hospital of Wisconsin
Chairman and professor, the Medical College of Wisconsin

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226
(414) 337-7770

Overview

Best Doctors 2013Dr. Lane’s research focuses upon how perinatal events lead to adult disease. His expertise is how these perinatal events impact the epigenetic characteristics and subsequent expression of specific genes. In 2003, we published our first manuscript on how intrauterine growth restriction (IUGR) affects renal p53 DNA methylation. Our subsequent manuscripts were among the first to demonstrate pronounced gender specificity in the perinatal epigenetic response. Moreover, our publications introduced the concept that many key epigenetic responses to the perinatal environment occur outside the promoter and may even include the 3’ UTR. This concept is important because it mechanistically allows for an adaptive moderate response to an adverse perinatal environment, as opposed to a more severe response resulting from epigenetically modifying a dominant promoter, which typically occurs within the context of developmental ontogeny and tissue specificity. We included this latter finding and concept in our 2009 FASEB publication “Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene”. Our work was been coined the new “epigenetics” by Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. We are not a laboratory that has recently jumped on the epigenetic bandwagon by learning a new set of techniques. We are a laboratory that is fully committed to understanding the 1) mechanisms through which early life events affect epigenetic markers and 2) how the new epigenetic marks determine latter life phenotype.

Certifications
Neonatal-Perinatal Medicine
Areas of Interest
  • Neonatology
  • Fetal and neonatal determinants of adult disease
  • Epigenetics
  • Molecular genetics

Education & Awards

Education
  • 1989, Northwestern University Feinberg School of Medicine, MD
Residency
  • 1992, Children's Memorial Hospital (Chicago, IL)
Fellowship
  • 1995, McGaw Med Ctr of Northwestern Univ
Awards
  • 1989 Alpha Omega Alpha
  • 1992-1994 Pediatric Scientist Training Fellowship Award
  • 1997 NIDDK-ONRC Pilot Study Award
  • 1997 NICHD-CNRC Junior Faculty Award
  • 1999 NICHD CIDA Award
  • 1999 MRRC New Program Development Award
  • 2001 Howard Hugs Prime Award
  • 2001 NICHD-CHRC Junior Faculty Award (UCLA)
  • 2003 WSPR Ross Award for Young Investigators
  • 2003 Member, NIH Sponsored Council – Improving Maternal Nutrition to Optimize Pregnancy
  • 2004 Invited Speaker, Perinatal Research Society Meeting
  • 2006 Invited Speaker, Inaugural SPR Pediatric Research Conference
  • 2007 Invited Participant, NIDDK Intrauterine Environment Workshop
  • 2007-2009 Council, Perinatal Research Society
  • 2010 Invited Speaker, National Academies Standing Committee on Emerging Science for Environmental Health Decisions - Use of In Utero and Post-Natal Indicators to Predict Health Outcomes Later in Life
  • 2011 Invited Participant, NICHD “Vision” Workshop on Developmental Origins of Health and Disease
  • 2011 Invited Participant, NICHD “Vision” Workshop on Pregnancy and Pregnancy Outcomes
  • 2011 Invited Speaker, NICHD Early Life Origins of Asthma: Strategies for Primary Prevention
  • 2011 Co-Chair, NHLBI Workshop on Molecular Determinants of Lung Development
  • 2011 President, Perinatal Research Society
  • 2012 Beta Gamma Sigma

Research & Publications

Publications