Jeanne M James, MD

Medical Director, Pediatric Cardiology, Children's Hospital of Wisconsin
The Leigh Gabrielle Herma Endowed Chair for Cardiology, Children's Hospital of Wisconsin Foundation
Section Chief, Pediatric Cardiology, Medical College of Wisconsin

Office locations

8915 W. Connell Ct.
Milwaukee, WI 53226
(414) 607-5280 (appointment)
(414) 266-2380 (clinic)
(414) 266-2434 (office)


Jeanne James, MD, has interest and expertise in general pediatric cardiology as well as Marfan syndrome, Loeys-Dietz syndrome and other diseases of the aorta. Throughout her career, Dr. James has been significantly invested in both cardiovascular research and in the training of medical students, residents and fellows in pediatric cardiology. Dr. James feels privileged to practice in the Herma Heart Center with a highly skilled multidisciplinary team of doctors, nurses, psychologists and social workers who are committed to the ideal of fostering a full and vibrant life for every patient.


Pediatric Cardiology
Areas of interest
  • Cardiology
  • Congenital heart disease
  • Cardiovascular genetics
  • Echocardiography
  • Marfan syndrome
  • Single ventricle heart disease

Education and awards

  • 1987, West Virginia University School of Medicine, MD
  • 1990, Vanderbilt University Medical Center - Pediatrics
  • 1994, Vanderbilt University Medical Center - Ped Cardiology

Research and publications

  1. Martherus R, Jain R, Takagi K, Mendsaikhan U, Turdi S, Osinska H, James J, Purevjav E and Towbin J.(2016) Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/b-catenenin signaling. Am J Physiol Heart Circ Physiol 310(2):H174-87. PMCID: 4796627.
  2. Huby A, Turdi S, James J, Towbin J and Purevjav E. (2016) FasL expression in cardiomyocytes activates ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure. Clin Sci (Lond) 130(4):289-99. PMID: 26566650.
  3. James J and Robbins J. (2016) Healing a heart through genetic intervention. Circ Res 118 (6):920-922. PMCID:PMC4801122.
  4. Gupta Manish, McLendon P, Gulick J, James J, Khalili K and Robbins J. (2016) UBC9-mediated SUMOylation favorably impacts cardiac function in compromised hearts. Circ Res 118 (12):1894-1905. PMCID:PMC4902739.
  5. Bakeer N, James J, Wansapura J, Shanmukhappa S, Osinska H, Subati T, Niss O, Quinn C, Purevjav E, Aronow B, Towbin J and Malik P. (2016) Sickle cell anemia mice develop a unique cardiomyopathy characterized by a progressive restrictive physiology and abnormal electrophysiology that predisposes to sudden death. Proc Natl Acad Sci USA 113(35):E5182-91. PMC5024607
  6. Bhuiyan Md. S, McLendon P, James J, Osinska H, Gulick J, Bhandary B, Lorenz J and Robbins J. (2016) In vivo definition of cardiac myosin binding protein C’s critical interactions with myosin. Pflugers Arch 468(10):1685-95. PMID: 27568194.
  7. Hinton R, Goldenberg P, Godby R, Parrott A, Shikany A, Landis B, James J, Miller E and Ware S. Left ventricular noncompaction in Noonan syndrome. In press.
  8. Hulin A, Moore V, James J and Yutzey K. Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. In press.
  9. Rogers LS, Klein M, James J and FitzGerald M. Needs assessment for cardiac morphology curriculum for pediatric cardiology fellows. In press.
  10. Alsaied T, Omar K, Hinton R, James J, Crombleholme T, and Habli M. Intra-placental gene transfer of human isulin-like growth factor-1 prevents fetal growth restriction induced cardiac dysfunction in a mouse model of fetal growth restriction. In press.