Adeleye J Afolayan, MD

Assistant professor, the Medical College of Wisconsin

Office Locations

8915 W. Connell Ave
Milwaukee, WI 53226


Dr. Afolayan is board certified in pediatrics and completed his fellowship training in Neonatal medicine at the Medical College of Wisconsin. He has special interest in managing preterm and term infants with various diseases particularly infants with difficult postnatal transition and pulmonary hypertension.

He enjoys working with residents and medical students to help them learn how to optimally care for infants in neonatal intensive care unit. Dr. Afolayan is a strong advocate for patients and families, and works with the child's pediatrician and parents to provide the best and most informed care possible.

Areas of Interest
  • Neonatology
  • Late preterm newborn care
  • Prematurity
  • Undiagnosed and rare diseases

Education & Awards

  • 1997, University of Ilorin Faculty of Health Science, MD
  • 2009, Bronx-Lebanon Hospital Center
  • 2012, Medical College of Wisconsin
  • The Best Resident of the Year, June 2009
  • The Best Research Resident of the Year, June 2009
  • Young Investigators award by pediatric academic society, March 2011
  • Fellows Research award, First place by Medical College of Wisconsin, April 2012
  • Young Investigators award by Pediatric Academic Society, April 2012


Selected recent publications
Dr. Afolayan’s research focuses on the role mitochondrial oxidative stress plays in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN). The mitochondria produce significant amount of superoxide radical during aerobic respiration. Superoxide anion is a powerful oxidant, which when in excess can damage the mitochondria and may lead to mitochondrial dysfunction. Superoxide dismutase isoforms (SODs) are important component of cellular antioxidant defenses that protect cell against oxidative damage. SOD2 is the gatekeeper in the mitochondrial matrix that removes excess superoxide radical produced to prevent oxidative stress. Our lab is using basic science approach to study the regulation of SOD2 and mitochondrial oxidative stress in the developing lungs using the fetal lamb model. His research interest is to better understand the regulation of pulmonary blood flow during postnatal transition.

  • Inducible HSP70 Regulates Superoxide Dismutase-2 and Mitochondrial Oxidative Stress in the endothelial cells from Developing Lungs.
  • Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn.
  • Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn.
  • AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension.

View all publications from Adeleye J. Afolayan, MD.