Funding and publications

Current funding

  • 1R01HL102745-01 (Ramchandran, R.) 2011-2015 - NIH/NHLBI. Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebrates - Role: PI
  • 1R01HL112639-01 (Ramchandran, R.) 2011-2016 - NIH/NHLBI. Targeting DUSP-5 to Treat Vascular Anomalies - Role: PI
  • 1R01HL111582-01 (Wodnicka, M. and Ramchandran, R.) 2012-2017 - NIH/NHLBI. Rap1 in VEGF signaling in endothelial cells - Role: Co-I
  • 1R01HL120585 (Mukherjee, P. and Ramchandran, R.) 2013-2018 - NIH/NHLBI. Cystathionine beta synthase (CBS) and angiogenesis - Role: Co-I
  • 1R01HL108938-01 (Miao, R. and Ramchandran, R.) – 2011-2016 - NIH/NHLBI. Role of NgBR - Role: Co-I
  • VITA (Ramchandran, R.) 2013-2016 - NIH/NHLBI. Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program - Role: PI
  • 2R44HL097465-02 (Ferrante, A. and Ramchandran, R.) 2012-2015 - NIH/NHLBI. Fully automated angiogenesis drug discovery assay in zebrafish – Phase II - Role: Co-I 
  • 2R01HL033833-29 (Harder, D and Ramchandran, R.) 2014-2019 - NIH/NHLBI. Astrocyte Secretome: Ability to Modify Phenotype and Genotype of Cells within CNS - Role: Co-I
  • NA (Gershan, J. and Ramchandran, R.) 2013-2014 - Basic Sciences Research Program Seed Grant, Medical College of Wisconsin Cancer Center (MCWCC). Identification of Factors that Promote Invasion and Metastasis of Epithelial Tumor Cells - Role: Co-I

Publications (2010-present)

  • Jia Y, Wu S-L, Isenberg JS, Sipes JM, Field L, Zeng B, Bandle RW, Ramchandran R, Karger BL and Roberts DD. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with the actin cytoskeleton. Cell Stress Chaperones 2010 Mar;15(2):165-81; PMC2866983
  • Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh N, Chun C, Samant G, Zhao B, Garnaas M, Horswill M, Stanhope S, North P, Miao R, Wilkinson G, Affolter M and Ramchandran R. A noncoding antisense RNA at the tie-1 locus regulates tie-1 transcript levels function in vivo. Blood 2010 Jan 7;115(1):133-9; PMC2803688
  • Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant G, Horswill M, Chun C, Mukhopadhyay D, Ramchandran R and Wilkinson G. Ecscr promotes angioblast migration during vasculogenesis and enhances kdr sensitivity. Blood 2010 Jun 3;115(22):4614-22; PMC2881497. **Inside Blood commentary: EC-specific chemotaxis receptor: a double-edged sword, p. 4614
  • Zhao B, Chun C, Liu Z, Horswill M, Pramanik K, Wilkinson G, Ramchandran R and Miao R. Nogo-B receptor is essential for angiogenesis in vivo via Akt pathway. Blood 2010. Dec 9;116(24):5423-33; PMC3012551
  • Chun CZ, Remadevi I, Schupp M, Samant GV, Pramanik K, Wilkinson GA and Ramchandran R. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. PLoS One 2011 Feb 25;6(2):e14732; PMC3045372
  • Lakshmikanthan S, Sobczak M, Chun CZ, Henschel A, Dargatz J, Ramchandran R and Chrzanowska-Wodnicka M. Rap1b regulates angiogenesis by an endothelial cell-autonomous mechanism involving integrin αvβ3-dependent VEGFR2 activation. Blood 2011 Aug 18;118(7):2015-26. Epub 2011 Jun 2; PMC3158727. (with “Inside Blood” commentary
  • Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P and Ramchandran R. Sox factors transcriptionally regulate robo4 expression in the developing vasculature in zebrafish. J Biol Chem. 2011 Sep 2;286(35):30740-7. Epub 2011 Jul 5; PMC3162435
  • Patra C, Kim J, Pramanik K, d’Uscio LV, Patra S, Ramchandran R, Strano M and Mukhopadhyay D. Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett. 2011 Nov 9;11(11):4932-8. Epub 2011 Oct 10; PMC3212653
  • Wickramasekera N, Gebremedhin D, Carver K, Vakeel P, Ramchandran R, Schuett A and Harder D. Role of dual-specificity protein phosphatase-5 (DUSP-5) in modulating myogenic response in rat cerebral arteries. Paper #: JAPPL-01026-2011R3. J Appl Physiol. 2013 Jan 15;114(2):252-61. PMID: 23172031 PMCID:PMC3544499
  • Kilari S, Remadevi I, Zhao B, Miao Q, Ramchandran R, North PE, Rahimi N and Wilkinson GA. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J Biol Chem. 2013 Apr 12;288(15):10265-74. PMCID: PMC3624410 [Available on 04/12/14
  • Span EA, Goodsell DS, Ramchandran R, Franzen M, Hemran T and Sem DS. Protein structure in context: The molecular landscape of angiogenesis. Biochem Mol Biol Educ. 2013 Jul-Aug;41(4):213-23 PMID: 23868376
  • Leigh NR, Schupp MO, Li K, Vakeel P, Gastonguay A, Wang, L, Chun CZ, Wilkinson GA and Ramchandran R. Mmp17b and its putative substrate Reck are essential for neural crest migration in vivo. PLoS ONE 2013 8(10):e76484. Doi:10.1371/journal.pone.0076484
  • Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR and Ramchandran R. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE 2013 Dec 4;8(12):e80933. Doi: 10.1371/journal.pone.0080933. PMCID: PMC3851470
  • Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP and Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014 Mar 15;23(60:1644-55. Doi: 10.1093/hmg/ddt556. PMCID: PMC 3929098.

* Denotes Joint First-Author