George A. Wilkinson, PhD

Titles
Investigator, Children's Research Institute; assistant professor, Pediatrics, Medical College of Wisconsin.

Division
Genetics

Research center/program
Developmental Vascular Biology Program

Research interests
Cell and developmental biology, genetic diseases/genomics

Study interests
Angiogenesis, developmental biology, mouse genetics, signal transduction.

Education
Doctorate, University of California, San Francisco, 1997; post-doctoral fellowships, EMBI, Heidelberg, Germany; Max-Planck Institute for Neurobiology, Martinsried, Germany.

Representative publications

• Wilkinson GA, Schittny JC, Reinhardt D, Klein R. Postnatal Lung Development and Extracellular Matrix Integrity Depend on Vascular EphrinB2 Function. Submitted.
• Bouzioukh F, Wilkinson GA, Adelmann G, Frotscher M, Stein V, Klein R. Tyrosine Phosphorylation Sites in EphrinB2 are Required for Hippocampal Long-term Potentiation, but no Long-term Depression. Journal of Neuroscience. In press.
• Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson, GA. PDZ Interaction Site in EphrinB2 is Required for the Remodeling of Lymphatic Vasculature. Genes and Development. 2005; 19(3):397-410.
• Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R. Kinase-independent Requirement of EphB2 Receptors in Hippocampal Synapticplasticity. Neuron. 2001; 32(6):1027-40.
• Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. Roles of EphrinB Ligands and EphB Receptors in Cardiovascular Development: Demarcation of Arterial/venous Domains, Vascular Morphogenesis and Sprouting Angiogenesis. Genes and Development. 1999; 13(3):295-306.
• Huang EJ, Wilkinson GA, Farinas I, Backus C, Zang K, Wong SL, Reichardt LF. Expression of Trk Receptors in the Developing Mouse Trigeminal Ganglion: In vivo Evidence for NT-3 Activation of TrkA and TrkB in Addition to TrkC.   Development. 1999; 126:2191-203.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2389
Fax: (414) 955-6325
E-mail: gwilkins@mcw.edu