Yi-Guang Chen, PhD 

Titles 
Investigator, Children's Research Institute, assistant professor, Pediatrics, The Medical College of Wisconsin.

Division
Endocrinology/Diabetes

Research center/program
Max McGee National Research Center for Juvenile Diabetes

Research interest
Diabetes/obesity

Study interests
Immunogenetics, type 1 diabetes.

Education
Doctorate, University of Rochester, Rochester, NY, 2002.

Honors
Graduate Fellowship, University of Rochester, NY, 2002; Postdoctoral Fellowship, Juvenile Diabetes Research Foundation International, 2005; Travel Award, Immunology of Diabetes Society 8th meeting (Japan), 2005; NIH K99 Pathway to Independence Award, 2010, NIH R00 Pathway to Independence Award, 2010-2013.

Representative publications

  • Chen YG, CM Choisy-Rossi, TM Holl, HD Chapman, GS Besra, SA Porcelli, DJ Shaffer, D Roopenian, SB Wilson, and DV Serreze. Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes. Journal Immunology. 2005;174:1196-1204.
  • Chen YG, J. Chen, MA Osborne, HD Chapman GS Besra, SA Porcelli, EH Leiter, SB Wilson, and DV Serreze. CD38 is Required for the Peripheral Survival of Immunotolerogenic CD4+ Invariant NK T Cells in Nonbese Diabetic Mice. Journal Immunology. 2006;177:2939-2947.
  • Chen YG, PA Silveira, MA Osborne, HD Chapman, DV Serreze. Cellular Expression Requirement for Inhibition of Type 1 Diabetes by a Dominantly Protective MHC Haplotype. Diabetes. 2007; 56:424-430.
  • Chen YG, JP Driver, PA Silveria, DV Serreze. Subcongenic Analysis of Genetic Basis for Impaired Development of Invariant NKT Cells in NOD Mice. Immunogenetics. 2007; 59:705-712.
  • Chen YG, F. Scheuplein, MA Osborne, SW Tsaih, HD Chapman, DV Serreze. The Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-cells in Non-obese Diabetic (NOD) Mice. Diabetes. 2008; 57:3273-3280.
  • Chen YG, F. Scheuplein, JP Driver, AA Hewes, PC Reifsnyder, EH Leiter, and DV Serreze. Testing the Role of P2X7Receptors in the Development of Type 1 Diabetes in Nonbese Diabetic Mice. Journal Immunology. 2011; 186:4278-84.

Grants

  • Genetic Control of Diabetogenic CD4 T Cells in NOD Mice (1-10-BS-26), American Diabetes Association, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (4R00DK077443-03), National Institutes of Health (NIH), National Instituite of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (24-2007-374), Juvenile Diabetes Research Foundation International, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (5K99DKO77443-02) National Institutes of Health (NIH), National Institute of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice - ARRA Administrative Supplement, (3K99DK077443-02S1Z), National Institutes of Health (NIH), National Institute of Diabetes and Digestive Kidney Disease, NIDDK, principal investigator.

Contact information
Medical College of Wisconsin
8701 Watertown Plank Road
Max McGee Center. HRC 5890
Milwaukee, WI 53226
Phone #: (414) 456-7583
Fax #: (414) 456-6516
E-mail address: yichen@mcw.edu

Investigator in areas of: