Alexandra F. Lerch-Gaggl, PhD 

Titles
Scientific director, Pediatric BioBank and Analytical Tissue Core, Children's Research Institute and The Medical College of Wisconsin; assistant professor, Pediatrics (Pathology), the Medical College.

Division
Pathology

Research center/program
Pediatric BioBank and Analytical Tissue Core

Research interests
Birthmarks and vascular anomalies, cancer, cell and developmental biology, genetic diseases/genomics, disease pathology

Study interests
Biospecimen science; pediatric vascular anomalies and cancers; molecular mechanisms of circadian rhythm and metabolism; molecular basics of ribosomal synthesis in regard to cancer formation

Education
Doctorate, University of Salzburg, Austria, 2000.

Honors

  • Individual Research Grant, 2007, American Cancer Society.
  • Travel Award, 2007, Federation for American Societies for Experimental Biology.
  • New Investigator Grant, 2006, Digestive Disease Center, the Medical College.
  • Northwestern Mutual Life Insurance Fellowship in Cancer Research, 2003, Viola Meinerz Foundation.
  • Best Postdoctoral Fellow Slide Presentation Award, 2002, American Association of Anatomists.
  • Travel Award, 2002, American Assocation of Anatomists.
  • Master of science degree with honors, 1996, University of Salzburg, Austria.

Representative publications

  • Lerch-Gaggl A, Haque J, Li J, Ning G, Traktman P, and Duncas SA. Pescadillo is Essential for Nucleolar Assembly, Ribosome Biogenesis, and Mammalian Cell Proliferation. J Biol Chem. 2002, 277:45347-45355.
  • Battle M, Konopka G, Parviz F, Lerch-Gaggl A, Yang C, Sladek FM and Duncan SA. Hepatocyte Nuclear Factor 4Orchestrates Expression of Cell Adhesion Proteins during the Epithelial Transformation of the Developing Liver. PNAS. 2006; 103 (22):8419-8424.
  • Lerch-Gaggl A, Sun K, and Duncan SA. Light Chain 1 of Microtubule Associated Protein 1B can Negatively Regulate the Action of Pes1. J Biol Chem. 2007; 282 (15):113908-16.
  • Leonardo SM, Harnett MM, Lerch-Gaggl AF, Gauld SB.  Fluorescence-based Assays as Tools for Understanding Immunologic Processes. Annals of Allergy, Asthma and Immunology. 2009; 102 (1):84-90.
  • Douris N, Kojima S, Pan X, Lerch-Gaggl AF, Duong SQ, Hussain MM, Green CB. Nocturnin Regulates Circadian Trafficking of Dietary Lipid in Intestinal Enterocytes. Current Biology. 2011; 21(16):1347-55.
  • El-Meanawy A, Stelloh C, Allen KP, Mattson DL, Lerch-Gaggl A and S. Reddy. Prematurity in Mice Leads to Reduction in Nephron Number, Hypertension, and Proteinuria. Translation Research. 2011.

Contact
Children's Research Institute, C4520
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2267
Fax: (414) 955-6411
E-mail: alerch@mcw.edu 

Investigator in the areas of: