Mitchell H. Grayson, MD

Titles
Pediatric asthma/allergist, Children's Hospital of Wisconsin; associate professor, The Medical College of Wisconsin.

Division
Asthma, allergy and immunology

Research interests
Allergies, asthma, cell and developmental biology, disease pathology, infectious/immunologic diseases, respiratory diseases.

Study interests
Asthma, atopy, dendritic cells, lung, virus, respiratory infection, food allergy.

Education
Medical degree, University of Chicago/Pritzker School of Medicine, Ill., 1993; residency, Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1993-1995; fellowship, Allergy and Immunology, Johns Hopkins University, Baltimore, Md., 1995-1998.

Certifications
Allergy and Immunology, 1999-2009; Internal Medicine, 1996-2006; Fellow, American Academy of Allergy, Asthma and Immunology; Fellow, American College of Allergy, Asthma and Immunology.

Honors
Professor Pro Tempore, The University of Mississippi Medical Center School of Medicine, Department of Medicine, 2007; Orchid Award, Asthma and Allergy Foundation of America, St. Louis Chapter, 2007; American Academy of Allergy, Asthma and Immunology Interest Section Award, 2004; Pharmacia Fellowship Award, 1999.

Representative publications

• Grayson MH, Hotchkiss RS, Karl IE, Holtzman MJ, Chaplin DD. Intravital Microscopy Comparing T-lymphocyte Trafficking to the Spleen and the Mesenteric Lymph Node. American Journal of Physiology: Heart and Circulatory Physiology. 2003: 284(6):H2213-26.
• Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ. Induction of High-affinity IgE Receptor on Lun Dendritic Cells During Viral Infection Leads to Mucous Cell Metaplasia. Journal of Experimental Medicine. 2007; 204(11):2759-2769.
• Akk A, Simmons PM, Chan H, Agapov E, Holtzman MJ, Grayson MH, Pham CTN. Dipeptidyl Peptidase I (DPPI)-dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection. Journal of Immunology. 2008; 180:3535-3542.
• Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit L, Byers D, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polenini D, Patterson, GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ. Persistent Activation of an Innate NKT Cell-macrophage Immune Axis Translates Respiratory Viral Infection intro Chronic Inflammatory Lung Disease. Nature Medicine. 2008; 14:633-640.
• Park SS, Ehlenbach SJ, Grayson MH. Lung Dendritic Cells and IgE: The Link Between Virus and Atopy. Future Medicine - Future Microbiology. 2008; 3:241-245.

• Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ. Controls for Lung Dendritic Cell Maturation and Migration During Respiratory Viral Infection. Journal of Immunology. 2007; 179(3):1438-48.

Grants

• National Institutes of Health, Ro1 HL087778, Dendritic Cells in Atopic and Virus-induced Airway Disease, principal investigator.
• NIH, R21 A1079905, Induction of Food Allergy by Intestinal Dendritic Cells, principal investigator.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-5648
Fax: (414) 456-6487
E-mail: mgrayson@mcw.edu