Hao Xu, PhD 

Titles
Investigator, Children's Research Institute, assistant professor, Pediatric Surgery, Medical College of Wisconsin.

Division
Surgery

Research center/program
Developmental Vascular Biology Program.

Research interests
Cancer, cell and developmental biology, diabetes/obesity, heart disease.

Study interests
Nitric oxide synthase, extracellular matrix, oxidative stress, chronic inflammation.

Education
Doctorate, University of Tromso, Norway, 2003.

Representative publications

• Xu H, El-Gewely MR. Differentially Expressed Downstream Genes in Cells with Normal or Mutated p53. Oncology Research. 2003; 13:112-119.
• Ou J, Wang J, Xu H, Ou Z, Sorci-Thomas MG, Jones DW, Signorino P, Densmore JC, Kaul S, Oldham KT and Pritchard Jr KA. Effects of D-4F on Vasodilation and Vessel Wall Thickness in Hypercholesterolemic LDL Receptor-null and LDL Receptor/Apolipoprotein A-1 Double-knockout Mice on Western Diet. Circulation Research. 2005; 97:1085-1086.
• Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones D, Kaul S, Komorowski R, Csuka M, Oldham K and Pritchard Jr KA.  Effects of D-4F on Vasodilation, Oxidative Stress, Angiostatin, Myocardial Inflammation and Angiogenic Potential in Tight-skin Mice. AJP: Heart and Circulatory Physiology. 2007; 293:H1432-H1441.
• Xu H, Shi Y, Wang J, Jones D, Weihrauch D, Ying R, Wakim B, and Pritchard Jr KA. A hsp90 Binding Domain in Endothelial Nitric Oxide Synthase (eNOS) Influences Enzyme Function. Journal of Biological Chemistry. 2007; 282:37567-37574.
• Xu H and Pritchard Jr KA. Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-dependent Nitric Oxide Production, not Uncoupled eNOS Activity. Arterioscler Thrombosis Vascular Biology. 2008; 28:1580-1581.
• Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard Jr KA and Shi Y. Identification of Proteins Interacting with GTP Cyclohydrolase 1. Biochemistry Biophysics Research Community. 2009; 385:143-147.
  

Grants

• Impact of Oxidative Modification of Extracellular Matrix Proteins on eNOS Translocation and Protein-protein Interactions, Medical College of Wisconsin, principal investigator.

Contact information
Children's Research Institute
8701 Watertown Plank Road
Milwaukee, WI 53226
Phone: (414) 955-2432
Fax: (414) 955-6473
E-mail: haoxu@mcw.edu