Hao Xu, PhD 

Titles
Investigator, Children's Research Institute, assistant professor, Pediatric Surgery, The Medical College of Wisconsin.

Division
Surgery

Research center/program
Developmental Vascular Biology Program.

Research interests
Bleeding and blood disorders, cancer, dermatologic diseases, diabetes/obesity, heart disease.

Study interests
Oxidative stress, eNOS, endothelial dysfunction, extracellular matrix, fibronectin, oxidative modification, inflammation, angiogenesis, senescence.

Education
Doctorate, University of Tromso, Norway, 2003.

Honors
AHA Midwest Affiliate Postdoctoral Fellowship award, 2005-2006.

Representative publications

• Xu H and Pritchard KA Jr. Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-dependent Nitric Oxide Production, not Uncoupled eNOS Activity. Arterioscler Thrombosis Vascular Biology. 2008; 28:1580-1581.
• Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard Jr KA and Shi Y. Identification of Proteins Interacting with GTP Cyclohydrolase 1. Biochemistry Biophysics Research Community. 2009; 385:143-147. PMCID: 2737525.
• Whitehouse JS, XU H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA, Oldham KT, Gourlay DM. Mesenteric Nitric Oxide and Superoxide Production in Experimental Necrotizing Enterocolitis. Journal of Surgical Research. 2010; 161(1):1-8. PMCID in process.
• Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, and Pritchard KA. Genetic Deletion of Apolipoprotein A-1 Increases Airway Hyperresponsiveness, Inflammation and Collagen Deposition in the Lung. Journal of Lipid Research.  2010; 51(9):2560-70. PMCID in process.
• Nandedkar SD, Weihrauch D, XU H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Prichard KA Jr. D-4F, an ApoA-1 Mimetic, decreases Airway Hyperresponsiveness, Inflammation and Oxidative Stress in a Murine Model of Asthma. Journal of Lipid Research. 2011; 52(3):499-508. PMCID in process.
• Teng R-J, Du J-H, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA, Jr. and Konduri GG. Sepiapterin Improves Angiogenesis of Pulmonary Artery Endothelial Cells with Inutero Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Am J Physiol Lung Cell Mol Physiol. 2011; accepted. PMCID in process.
  

Grants

• National Institutes of Health, The Role of Oxidatively Modified Fibronectin in Atherosclerosis, principal investigator, pending.

Contact information
Children's Research Institute
TBRC, CRI C4450
8701 Watertown Plank Road
Milwaukee, WI 53226
Phone: (414) 955-2432
Fax: (414) 955-6473
E-mail: haoxu@mcw.edu

Investigator in the areas of:

• Cardiovascular biology