Kirkwood A. Pritchard, JR., PhD 

Titles
Investigator, Children's Research Institute; professor, Surgery, Pharmacology and Toxicology, vice chair, Research Surgery, chairman, Research Affairs Committee, director, Translational Vascular Biology Program, The Medical College of Wisconsin.

Division
Surgery

Research interests
Allergies, bleeding and blood disorders, sickle cell anemia, dermatologic diseases, diabetes/obesity, disease pathology, gastrointestinal diseases, heart disease, respiratory diseases, asthma.

Study interests
Vascular inflammation, oxidative stress, asthma, sickle cell disease, systemic sclerosis.

Education
Doctorate, Ohio State University, Columbus, 1983; postdoctoral fellow, Albert Einstein College of Medicine, Bronx, N.Y., 1985.

Certifications
American Board of Clinical Chemistry, September 1999, board certified.

Representative publications:

• Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard Jr KA, Oldham KT.  Protein Composition of Plasminogen Activator Inhibitor Type 1-Derived Endothelial Microparticles. Shock. 2008; 29(4):504-511.
• Peterson DB, Sander T, Kaul S, Wakim BT, Halligan B, Twigger S, Pritchard Jr KA, Oldham KT, Ou JS. Comparative Proteomic Analysis of PAI-1 and TNF-alpha-derived Endothelial Microparticles. Proteomics. 2008 June; 8(12):2430-46.
• Frei AC, Guo Y, Jones DW, Pritchard Jr KA, Fagan KA, Hogg N. Wandersee NJ. Vascular Dysfunction in a Murine Model of Severe Hemolysis. Blood. 2008 July; 112(2):398-405.
• Xu H, Pritchard Jr KA. Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNos-dependent Nitric Oxide Production, Not Uncoupled eNOS Activity. Arteiscler Thromb Vascular Biology. 2008; 28:1580-1581.
• Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard Jr KA. Histopathology of Experimentally-induced Asthma in a Murine Model of Sickle Cell Disease. Blood. 2008;112(6):2529-38.
• Larsen BT, Bubolz AH, Mendoza SA, Pritchard Jr KA, Gutterman DD. Bradykinin-induced Dilation of Human Coronary Arterioles Requires NADPH Oxidase-derived Reactive Oxygen Species. Arterioscler Thromb Vascular Biology. 2009 Feb. (in press).

Grants

• Vascular Signaling by Free Radicals, Project #1 Modification of Vascular Signaling in the Brain by ROS, National Heart, Lung and Blood Institute, co-investigator.
• Vascular Signaling by Free Radicals, Project #2 Role of Reactive Oxygen Species in Flow-Mediates Vasodilation, NHLBI, co-investigator.
• Native LDL, Cholesterol and Impaired Vasodilation, NHLBI R01, principal investigator.
• Regulation of Pulmonary Circulation in Fetus and Newborn, NHLBI, co-investigator.
• Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia, Subcontract of NIH RFA to Michael DeBaun, MD, Washington University, St. Louis, MO, co-investigator in RFA, principla investigator for the Milwaukee site.
• HDL Dysfunction and Vascular Inflammation, NHLBI RO1, principal investigator.
• Role of Microfibril and Connective Tissue Function in Endothelial Mesenchymal Transition, MCW Clinical and Translation Science Institute, co-investigator.

Contact
Children's Research Institute
8701 Watertown Pklank Road
Milwaukee, WI 53226
Phone: (414) 955-5615
Fax: (414) 955-6473
E-mail: kpritch@mcw.edu