Andrew Chan, PhD 

Titles
Investigator, Children's Research Institute, professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin.

Division
Hematology/Oncology/BMT

Research interests
Cancer, cell/developmental biology

Study interests
Oncogenes, tumor suppressors, mouse models of human cancer.

Education
Doctorate, University of London, 1988.

Honors
Fogarty International Fellow, 1989-1992; Irma T. Hirschl Career Scientist Award, 1996-2001.

Representative publications

• Tolkacehva T, Boddapati M, Sanfiz A, Tsuchida K, Kimmelman AC, Chan, AM. Regulation of PTEN Binding to MAGI-2 by two Putative Phosphorylation Sites at Threonine Codon 382 and 383. Cancer Research. 2001; 61:4985-4989.
• Goutham N, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martgnetti JA, Friedman SL. KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science. 2001; 294:2563-2566.
• Kimmelman AC, Nunez-Rodriguez N, Chan AM. R-Ras3/M-Ras induces Differentiation of PC!2 Cells through a Cell-Type Specific Activation of the Mitogen-Activated Protein Kinase. Molecular Cellular Biology. 2002; 22:5946-5961.
• Kimmelman AC, Qiao RF, Narla G, Sanfiz A, Bos P, Banno A, Nunez-Rodriguez N, Lau N, Li D, Eng FJ, Beaven S,  Benzeno S, Liang BC, Guha A, Martignetti JA, Friedman SL and Chan AM. Suppression of Glioblastoma Tumorigenicity by the Kruppel-like Transcription Factor, KLF6. Oncogene, 23:5077-5083.
• Rodriguez NN, Lee IN, Banno A, Qiao HF, Qiao RF, Hoang T, Kimmelman AC and Chan AM. Characterization of R-Ras3/M-Ras Null Mice Reveals a Potential Role in Trophic Factor Signaling. Molecular Cellular Biology. 2006; 26:7145-7154.
• Odriozola L, Singh G, Hoang T, and Chan AM. Regulation of PTEN Activity by its Carboxyl-terminal Autoinhibitory Domain. Journal Biology Chemistry. 2007; 282:23306-23315.

Grants

• Regulation of Glioblastoma Migration by PTEN PDZ-binding Domain, NCI-NIH. Pending

Contact
Department of Pediatrics
Division of Hematology/Oncology/BMT
Medical College of Wisconsin
8701 Watertown Plank Road
MFRC - 6033
Milwaukee, WI 53226
Phone: (414) 456-5659
Fax: (414) 456-6543
e-mail: axchan@mcw.edu