Research lab: Adrinus Domen, PhD; and Kimberly Gandy, MD, PhD
Leadership
Research in Cardiac Surgery
Dr. Domen has a long-standing interest in the biology of hematopoietic stem cells and their regulation by apoptosis. Dr. Gandy has studied aspects of allogeneic hematopoietic cell transplantation with a focus on their use in tolerance induction.
The joint lab effort Drs. Gandy and Domen focuses on two areas:
- The use of hematopoietic stem cells and bone marrow cells in tolerance induction for solid organ transplantation. Organ transplantation is successful, but requires continued immunosuppression to prevent rejection of the transplanted organ. This leads to complications, including ongoing vulnerability to infection. It is known that a bone marrow transplantation from the organ donor can result in acceptance of the transplanted organ. They are investigating ways to improve bone marrow transplantation to the point that use for tolerance induction can become clinically accepted. This is in addition to the already widespread use of bone marrow transplantations in cancer patients, who have different needs than transplantation patients.
- The unexplained ability of bone marrow cells to contribute to recovery of myocardial function. This has been documented mostly in myocardial infarct models in different animal systems and in clinical studies in humans. Their research in this area uses mouse models of congenital cardiomyopathy. They observed improved function after bone marrow injection without clear evidence of engraftment in the heart of bone marrow-derived cells. They currently are investigating possible mechanisms that could help explain these observations.
Medical College of Wisconsin laboratory Web site.
Grants
- The Use of Autologous Hematopoietic Stem Cells in Tolerance Induction for Organ Transplantation, Thoracic Surgery Foundation for Research and Education Nina Starr Braunwald Award, principal investigator: Kimberly Gandy, MD, PhD, co-investigator: Jos Domen, PhD.
- The Use of Bone Marrow to Reduce Damage Due to Cardiomyopathy, Children's Research Institute Pilot Initiative Research Award, principal investigator: Jos Domen, PhD, co-investigator: Kimberly Gandy, MD, PhD.
- The Use of Myeloid Progenitors to Improve Immune Competence After HSC Transplantation for Tolerance Induction, Advancing a Healthier Wisconsin, principal investigator: Jos Domen, PhD, co-investigator: Kimberly Gandy, MD, PhD.
- The Immune Competence of Children after Congenital Heart Surgery, Medical College of Wisconsin-CTSI, principal investigator: Kimberly Gandy, MD, PhD, co-investigator: Jos Domen, PhD.
Publications from team
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Gandy KL, Rebeiz AG, Wang A, Jaggers JJ. Left Main Coronary Artery to Pulmonary Artery Fistula with Severe Aneurysmal Dilatation. The Annals of Thoracic Surgery. 2004 Mar.; 77(3):1081-3.
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Gandy KL, Burtelow M, Reddy VM, Silverman N. Myofibroblastic Tumor of the Heart: a Very Rare Intracardiac Tumor. Journal of Thoracic Cardiovascular Surgery. 2005; 130(3):888-9.
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Gandy KL, Hanley FL. Management of Systemic Venous Anomalies in the Pediatric Cardiovascular Surgery Patient. Pediatric Cardiac Surgery Annual. 2006; 9(1):63-74.
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Nigro JJ, Choi S, Graziano J, Gandy KL, Guerrero-Tiro LM, Cleveland DC. Modified Superior Repair for Supracardiac Total Anomolous Pulmonary Venous Connection in the Adult. The Annals of Thoracic Surgery. 2007 Jul.; 84(1)312-3.
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Redford DT, Quigley TW, Gandy KL, Barber BJ. Transesophageal Echocardiography for the Intraoperative Evaluation and Management of a Left Ventricular Vegetation. Anesthesia and Analgesia. 2008, in press.
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Gandy KL, Moulton MJ. Sternal Plating to Prevent Malunion of Transverse Sternotomy in Lung Transplantation. The Annals of Thoracic Surgery. In press. |
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