Adrianus (Jos) Domen, PhD
Titles
Investigator, Children's Research Institute; assistant professor, Pediatrics (Cardiothoracic), Medical College of Wisconsin.
Division
Cardiothoracic Surgery
Research center/program
Herma Heart Center
Research interests
Heart disease, solid organ transplantation.
Study interests
Heart transplant
Education
Doctorate, Netherlands Cancer Institute/University of Amsterdam, 1993; postdoctoral fellow, Stanford University School of Medicine, Palo Alto, Calif., 1999.
Representative publications
Chen BJ, Cui X, Sempowski GD, Domen J, Chao NJ. Hematopoietic Stem Cell Dose Corelates with the Speed of Immune Reconstitution After Stem Cell Transplantation. Blood. 2004; 103:4344-4352.
Bouton LA, Ramirez CD, Bailey DP, Yeatman CF, Yue J, Wright HV, Domen J, Rosato RR, Grant S, Fischer-Stenger K, Ryan JJ. Costimulation with Interleukin-4 and Interleukin-10 Induces Mast Cell Apoptosis and Cell-arrest: The Role of P53 and the Mitochondrion. Experimental Hematology. 2004; 32:1137-1145.
Federov LM , Schmittwolf C, Amann K, Thomas WH, Muller AM, Schubert H, Domen J, Kneitz B. Renal Failure Causes Early Death of Bcl-2 Deficient Mice. Mechanisms of Ageing and Development. 2006; 127:600-609.
Domen J, Christensen J, Danenberg E, Smith-Berdan SJ, Fong T, Brown J. Ex vivo Expanded Cyopresereved Allogeneic Myeloid Progenitors Protect Against Lethal Invasive Aspergillosis in Neutropenic Mice. In preparation, 2008.
Grants
- The Use of Autologous Hematopoietic Stem Cells in Tolerance Induction for Organ Transplantation, Thoracic Surgery Foundation for Research and Education Nina Starr Braunwald Award, principal investigator: Kimberly Gandy, MD, PhD, co-investigator: Jos Domen, PhD.
- The Use of Bone Marrow to Reduce Damage Due to Cardiomyopathy, Children's Research Institute Pilot Initiative Research Award, principal investigator: Jos Domen, PhD, co-investigator: Kimberly Gandy, MD, PhD.
- The Use of Myeloid Progenitors to Improve Immune Competence After HSC Transplantation for Tolerance Induction, Advancing a Healthier Wisconsin, principal investigator: Jos Domen, PhD, co-investigator: Kimberly Gandy, MD, PhD.
- The Immune Competence of Children after Congenital Heart Surgery, Medical College of Wisconsin-CTSI, principal investigator: Kimberly Gandy, MD, PhD, co-investigator: Jos Domen, PhD.
Contact
Children's Research Institute
8701 Waterown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2498
E-mail: adomen@mcw.edu
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