James Tweddell, MD

Titles
S. Bert Litwin Chair, Cardiothoracic Surgery, Children's Hospital of Wisconsin.
Professor and pediatrics chair, Cardiothoracic Surgery, the Medical College of Wisconsin.

Specialties
Cardiothoracic Surgery
Cardiothoracic Surgery, Pediatric

Research Interests
Heart disease

Board Certifications

  • American Board of Surgery-Certified-Surgery
  • American Board of Thoracic Surgery-Certified-Thoracic Surgery
  • American Board of Thoracic Surgery-Certified-Congenital Cardiac Surgery

Video Profile

Meet Dr. Tweddell and learn about congenital heart surgery at Children's Hospital of Wisconsin by watching the following video:

Education

MD: University of Cincinnati, 1981 - 1985.
Internship: New York University, NY (General Surgery) 1985 - 1986.
Residency: New York University, NY (General Surgery) 1986 - 1987.
Residency: Washington University, St. Louis, MO (General Surgery) 1987 - 1991.
Fellowship: Washington University, St. Louis, MO (Thoracic-Cardiovascular Surgery) 1991 - 1993.
Fellowship: Washington University, St. Louis, MO (Pediatric Thoracic-Cardiovascular Surgery) 1991 - 1993.

Employment 

  • 1993: Instructor in Surgery, Division of Cardiothoracic Surgery, Washington University Medical Center, St. Louis, Missouri.
  • 1994: Assistant Professor of Surgery and Pediatrics, Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee.
  • 1994-1996: Director of Heart Transplantation, Division of Cardiothoracic Surgery, The Medical College of Wisconsin and John L. Doyne Hospital, Milwaukee.
  • 1995-Present: Director of Cardiothoracic Transplantation, Children's Hospital of Wisconsin, Milwaukee.
  • 1996-2000: Director of Heart Transplantation, Division of Cardiothoracic Surgery, The Medical College of Wisconsin and, Froedtert Memorial Hospital, Milwaukee.
  • 1998: Associate Professor of Surgery, Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee.
  • 2001-Present: S. Bert Litwin Chair in Cardiothoracic Surgery, Childrenís Hospital of Wisconsin, Milwaukee.
  • 2001-Present: Director, Pediatric Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee.
  • 12/02-06/04: Interim Chief, Division Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee.
  • 2002-2007: Director, Cardiothoracic Residency Program, Veterans Memorial Medical Center, Milwaukee.
  • 2002-2007: Director, Cardiothoracic Surgery Residency Program, The Medical College of Wisconsin, Milwaukee.
  • 2003-Present: Professor of Surgery (Cardiothoracic) and Associate Professor of Pediatrics, The Medical College of Wisconsin, Milwaukee.
  • 2003-2006: Director, Pediatric Cardiothoracic Surgery, Department of Thoracic and Cardiovascular Surgery, Loyola University Medical Center, Maywood, Illinois.
  • 2003-Present: Professor of Surgery (Cardiothoracic) and Pediatrics, The Medical College of Wisconsin, Milwaukee.
  • 2004-Present: Chief, Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee.

 Committees/Professional Societies

  • Memberships in Professional and Honorary Societies

American Academy of Pediatrics
American Association for Thoracic Surgery
American College of Cardiology
American College Chest Physicians
American College of Surgeons
American Heart Association
Congenital Heart Surgeons' Society
International Society for Heart and Lung Transplantation
Medical Society of Milwaukee County
Midwest Pediatric Cardiology Society 
Milwaukee Surgical Society
Society of Thoracic Surgeons
Society of University Surgeons
State Medical Society of Wisconsin
Southern Thoracic Surgical Association
Thoracic Surgery Directors Association
21st Century Cardiac Surgical Society

  • Regional/Local/Appointed Leadership and Committee Positions

1994-2004: Chairman, Thoracic Transplant Committee, Children's Hospital of Wisconsin
2001: Wisconsin Donor Network Advisory Board
2001: Medical Executive Staff Committee, Children's Hospital of Wisconsin
2001: OR Executive Committee, Children's Hospital of Wisconsin
2001: Joint Patient Care Committee, Children's Hospital of Wisconsin
2001: Hospital Advisory Committee, Froedtert Memorial Lutheran Hospital

  • National Elected/Appointed Leadership and Committee Positions

1997-1999: United Network of Organ Sharing, Thoracic Organ Transplant Committee, Region 7 Representative
2001-2003: United Network of Organ Sharing, Heart Regional Review Boar
2002-2003: Pediatric Heart Disease Clinical Research Network, Data and Safety Monitoring Board
2003-2005: United Network of Organ Sharing, Pediatric Transplantation Committee. At Large Committee Member
2006-Present: Ad Hoc reviewer NIH Cardiovascular Sciences Small Business Study Section (ZRG1 CVS-K 10
2006-Present: The Society of Thoracic Surgeons (STS) Workforce on Congenital Heart Surgery
2006-2009: American Association for Thoracic Surgery Education Committee
2006-Present: Society of Thoracic Surgeons: Accreditation Committee - Perfusion Education
2007-Present: American Association for Thoracic Surgery - Program Committee
2007-Present: American College of Cardiology ñ Program Committee
2008: American Heart Association. Prevention and Treatment Of Thrombosis in Children and Adults with Congenital Heart Disease And in Children with Acquired Heart Disease: AHA Scientific Statement
2008: American College of Cardiology & Adult Congenital and Pediatric Cardiology Section
2008: Society of Thoracic Surgeons: Workforce on Peer Review and Evaluation.
2009: Pediatric Heart Network, National Heart Lung and Blood Institute,  Perioperative Working Group, Co-Chair, Novel Surgical Procedures Subcommittee.
2009: American Academy of Pediatrics: Section on Cardiology and Cardiac Surgery Executive Committee.
2009: Congenital Heart Surgeonsí Society: Anomalous Aortic Origin of the Coronary Artery & Working Group.
2010: American Board of Thoracic Surgery: Congenital Heart Surgery Society Consultants Committee.
2011: American Heart Association: Writing Group & Cardiopulmonary Resuscitation in Infants and Children with Cardiac Disease: AHA Scientific Statement.
2012: The American Board of Thoracic Surgery

 Research

  • Principal Investigator: James S. Tweddell, MD, Tolerance of Hypoxemia Immature Heart to Surgical Ischemia. Children's Hospital Foundation, 1995-1996, $111,297.
  • Principal Investigator: James S. Tweddell, MD, Tolerance of the Immature Cyanotic Heart to Ischemia. Medical College of Wisconsin, 1994, $10,000.
  • Principal Investigator: James S. Tweddell, MD, Comparison of Blood Cardioplegia plus Hypothermia to Hypothermia Alone. Medical College of Wisconsin, 1994, $7000.
  • Principal Investigator: James S. Tweddell, MD, The Inflammatory Response to Cardiopulmonary Bypass in Neonates and Infants. Children's Hospital Foundation, 1997-2000, $48,600.
  • Principal Investigator: James S. Tweddell, MD, The Inflammatory Response to Cardiopulmonary Bypass in Neonates and Infants. Bayer Corporation 1997-2000, $48,600.
  • Principal Investigator: James S. Tweddell, MD, PETñ205: A Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of CY-1503 (Cylexin) in the Prevention of Reperfusion Injury in Neonates and Infants Undergoing Hypothermic Cardiopulmonary Bypass during Surgical Repairs of Congenital Heart Defects (CHW 98/11, HRRC 75098). Cytel Corporation, 1998-1999, $120,601.
  • Principal Investigator: James S. Tweddell, MD, Pediatric Development. Medical College of Wisconsin, 1999-2008, $22,845.
  • Principal Investigator: James S. Tweddell, MD, Seprafilm II Adhesion Barrier in Pediatric Cardiac Surgery. Genzyme Corporation, 1999-2000, $7,000.
  • Principal Investigator: James S. Tweddell, MD, Nitric Oxide and Tolerance of Hypoxia Heart to Ischemia. Children's Hospital Foundation, 2000-2001, $50,000.
  • Principal Investigator: James S. Tweddell, MD, Pharmacokinetics of Brevibloc for Treatment of Hypertension Baxter Pharmaceutical Products Inc. 2000-2001, $13,070.
  • Co-Principal Investigator: James S. Tweddell, MD, Prophylactic use of Primacor (Milrinone) in Pediatric Patients at High Risk of Developing Low Cardiac Output Following Cardiac Surgery. Sanofi-Synthelabo, 2000-2002, $72,460.
  • Principal Investigator: James S. Tweddell, MD, Berlin Heart EXCOR Pediatric Ventricular Assist Device. Berlin Heart Inc, 2007-2011, $54,775.
  • Principal Investigator: James S. Tweddell, MD, S. Bert Litwin Chair in Cardiothoracic Surgery for 2009. Children's Hospital Foundation 01/01/09 - 12/31/09, $24,723.
  • Principal Investigator: James S. Tweddell, MD, CryoValve SG Human Pulmonary Valve Follow-up Study. Cryolife, Inc, 2007-2012, $9650.
  • Principal Investigator: James S. Tweddell, MD, CryoValve SG Pulmonary Human Heart Valve Post-Clearance Study. Cryolife, Inc, 2009-2011, $37,900.

 Publications (selected journal publications 10 of 91)

  • Tweddell JS, Hoffman GM, Mussatto KA, Fedderly RT, Berger S, Jaquiss RD, Ghanayem NS, Frisbee SJ, Litwin SB. Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients. Circulation 2002;106:82-89.
  • Ghanayem NS, Hoffman GM, Mussatto KA, Cava JR, Frommelt PC, Rudd NA, Steltzer MM, Bevandic SM, Frisbee SS, Jaquiss RD, Litwin SB, Tweddell JS. Home surveillance program prevents interstage mortality after the Norwood procedure. J Thorac Cardiovasc Surg 2003;126:1367-1377.
  • Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto, KA, Stuth EA, Jacquiss RD, Berger S. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the norwood procedure. J Thoracic Cardiovasc Surg 2004;127:738-745.
  • Hoffman GM, Stuth EA, Jaquiss RD, Vanderwal PL, Staudt SR, Troshynski TJ, Ghanayem NS, Tweddell JS. Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion. J Thorac Cardiovasc Surg 2004;127:223-233.
  • Jaquiss RD, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS. Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality. J Thorac Cardiovasc Surg 2004;127:982-989.
  • Hoffman GM, Mussatto KA, Brosig CL, Ghanayem NS, Musa N, Fedderly RT, Jaquiss RD, Tweddell JS. Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg 2005;130:1094-1100.
  • Jaquiss RD, Siehr SL, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS. Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome. Ann Thorac Surg 2006;82:1260-1265.
  • Tweddell JS, Ghanayem NS, Mussatto KA, Mitchell ME, Lamers LJ, Musa NL, Berger S, Litwin SB, Hoffman GM. Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. Ann Thorac Surg 2007;84:1301-1310; discussion 10-1.
  • Tweddell JS, Nersesian M, Mussatto KA, Nugent M, Simpson P, Mitchell ME, Ghanayem NS, Pelech AN, Marla R, Hoffman GM. Fontan palliation in the modern era: factors impacting mortality and morbidity. Ann Thorac Surg 2009;88:1291-1299.
  • Johnson BA, Hoffman GM, Tweddell JS, Cava JR, Basir M, Mitchell ME, Scanlon MC, Mussatto KA, Ghanayem NS. Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome. Ann Thorac Surg 2009;87:571-577.

 

Contact
Children's Hospital of Wisconsin
Herma Heart Center
PO Box 1997
Milwaukee, WI 53201-1997
Phone: (414) 266-2638
E-mail: jtweddell@chw.org

Investigator in the areas of: