James Tweddell, MD

Titles
Medical director, Cardiothoracic Surgery, Children's Hospital of Wisconsin; professor, Surgery (Cardiothoracic), and chair, Cardiothoracic Surgery, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research interests
Cardiopulmonary bypass, pediatric cardiac critical care, pediatric cardiac surgery.

Education
Medical degree, University of Cincinnati College of Medicine, Ohio, 1985; intern and resident, General Surgery, New York University Medical Center, 1987; research fellow, Cardiothoracic Surgery, Washington University Medical Center, St. Louis, 1989; senior resident and chief resident, General Surgery, Washington University Medical Center, St. Louis, 1991; resident, Cardiothoracic Surgery, Washington University Medical Center, St. Louis, 1993; fellow, Pediatric Cardiothoracic Surgery, Washington University Medical Center, St. Louis Children's Hospital, 1993.

Honors
Alpha Omega Alpha, University of Cincinnati College of Medicine, 1985; Fleischmann Scholarship, University of Cincinnati College of Medicine, 1983; Lange Medical Publications Award, University of Cincinnati College of Medicine, 1985.

Representative publications

• Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ. Darbepoetin Alfa Protects the Rat Heart Against Infarction: Dose-response, Phase of Action and Mechanisms. Journal of Cardiovascular Pharmacology. 2007; 49(6):337-45.
• Frommelt PC, Sheridan DC, Mussatto KA, Hoffman GM, Ghanayem NS, Frommelt MA, Tweddell JS. Effect of Shunt Type on Echocardiographic Indices After Initial Palliations for Hypoplastic Left Heart Syndome: Blalock-Taussig Shunt Versus Right Ventricle-pulmonary Artery Conduit. Journal of American Society Echocardiograph. 2007 Jun. 29.
• Tweddell JS. Aspirin: A Treatment for the Headache of Shunt-dependent Pulmonary Blood Flow and Parallel Circulation? Circulation. 2007 Jul. 17; 116(3):236-7.
• Ghanayem NS, Berger S, Tweddell JS. Medical Management of the Failing Fontan. Pediatric Cariology. 2007 Aug. 31.
• Baker JE, Su J, Fu X, Hsu A. Gross GJ, Tweddell JS, Hogg N. Nitrite Confers Protection Against Myocardial Infarction: Role of Xanthine Oxidoreductase, NADPH Oxidase and K(ATP) Channels. Journal Molecular Cell Cardiology. 2007 Jul. 31.
• Tweddell JS, Ghanayem NS, Mussatto KA, Mitchell ME, Lamers LJ, Musa NL, Berger S, Litwin SB, Hoffman GM. Mixed Venous Oxygen Saturation Monitoring After Stage 1 Palliation for Hypoplastic Left Heart Syndrome. Annals of Thoracic Surgery. Accepted.

Contact
Children's Hospital of Wisconsin
Herma Heart Center
PO Box 1997
Milwaukee, WI 53201-1997
Phone: (414) 266-2638
E-mail: jtweddel@chw.org