Clinical effectiveness research is the systematic scientific evaluation of the outcomes of clinical care based on principles of clinical epidemiology. This includes clinical trials as well as diagnostic test evaluations and observational studies of outcomes of care.

Examples of clinical effectiveness and outcomes research underway at Children's Research Institute include:

• Participation in key national clinical trials network for hematology, oncology and bone marrow transplant.
• A randomized trial of ibuprofen versus acetaminophen with codeine for management of pain in children with fractures.
• A multicenter study to develop a clinical decision rule guiding the use of CT scanning in children with minor head injury.
• A study of the impact of family presence during trauma resuscitations on family coping and staff satisfaction.
• A multicenter, FDA-sponsored randomized trial of steroids versus vincristine for treatment of infantile hemangioma.
• A clinical trial to demonstrate the ability of erythropoietin to protect the infant human heart during surgical repair of congenital heart defects.

Research in clinical effectiveness is the means by which novel diagnostic methods and treatment approaches are evaluated to guide the development of best practices and provide the most effective and safest care for children.

• John Aiken, MD
• Ramin Alemzadeh, MD
• Catherine Amlie-Lefond, MD
• Marjorie Judith Arca, MD
• Anthony Balcom, MD, FACS, FAAP
• Peter J. Bartz, MD
• Adriane L. Baylis, PhD, CCC-SLP
• Kathleen R. Beckmann, DO, FAAP
• Stuart Berger, MD
• David Brousseau, MD, MS
• Casey Calkins, MD
• Bruce M. Camitta, MD
• James T. Casper, MD
• Laura Cassidy, PhD
• Joseph R. Cava, MD, PhD
• Pamela Cava, DO
• Asriani M. Chiu, MD
• Michael J. Chusid, MD
• Stephen Conley, MD, MS
• Lynn A. D'Andrea, MD
• Arlen D. Denny, MD
• Anwer Dhala, MD, FACC
• Amy Drendel, DO, MS
• Beth A. Drolet, MD
• Charles T. Durkee, MD
• Mary Eapen, MBBS, MS
• Michael Earing, MD
• Raymond T. Fedderly, MD
• Jordan Fink, MD
• Veronica Flood, MD
• David Friedberg, MD
• Michele Frommelt, MD
• Peter Frommelt, MD
• Kimberly Gandy, MD, PhD
• Stephen B. Gauld, PhD
• Rainer Gedeit, MD
• William M. Gershan, MD
• Nancy Ghanayem, MD
• Joan Cox Gill, MD
• Marc H. Gorelick, MD
• Peter L. Havens, MD
• Kelly J. Henrickson, MD
• John B. Hijjawi, MD
• George M. Hoffman, MD
• Kristen E. Holland, MD
• John Jensen, MD
• Bruce Kaufman, MD
• Joseph E. Kerschner, MD, FACS, FAAP
• Edward Kirkpatrick, MD
• Jane Kivlin, MD
• Frederick Klingbeil, MD
• Girija Ganesh Konduri, MD
• Mark A. Kostic, MD
• Viswanath Kurup, PhD
• Steven Leuthner, MD
• Michael B. Levy, MD
• Sean Lew, MD
• B U.K. Li, MD
• Xue-Cheng Liu, PhD, MD
• Stanley Lo, PhD
• Roger M. Lyon, MD
• Valerie Lyon, MD
• Shelly Malin, PhD, RN
• Karen Marcdante, MD
• David A. Margolis, MD
• Gail McCarver, MD
• Marlene D. Melzer-Lange, MD
• Hrair-George O. Mesrobian, MD
• Michael Ernst Mitchell, MD
• Elizabeth Moberg-Wolff, MD
• Kathleen A. Mussatto, BSN, RN
• James J. Nocton, MD
• Richard J. Noel, MD, PhD
• Judyann C. Olson, MD
• Paola Palma Sisto, MD
• Cynthia G. Pan, MD
• Julie A. Panepinto, MD, MSPH
• Andrew Pelech, MD
• Mike Quasney, MD, PhD
• Kimberly M. Rennie, PhD
• Colin D. Rudolph, MD, PhD
• Mark S. Ruttum, MD
• Ramesh C. Sachdeva, MD, PhD, MBA
• Margaret M. Samyn, MD, FAAP, FACC
• Thomas Sato, MD
• David E. Saudek, MD
• Matthew Scanlon, MD
• J. Paul Scott, MD
• Brian D. Shames, MD
• Eileen Sherburne, MSN, RN, FNP
• Pippa Simpson, PhD
• Manu Sood, MD
• Martha Stevens, MD, MSCE
• Janette F. Strasburger, MD
• Ernest Stremski, MD, MBA
• J. Channing Tassone, MD
• Grzegorz W. Telega, MD
• John G. Thometz, MD
• Neelesh A. Tipnis, MD
• Sajani Matai Tipnis, MD
• P. Ashley Wackym, MD, FACS, FAAP
• Steven J. Weisman, MD
• Rodney Willoughby, MD
• David T. Wyatt, MD
• Kenneth Yen, MD
• Michael C. Zacharisen, MD
• Steven D. Zangwill, MD
• Lisa Zetley, MD
• Mary L. Zupanc, MD