Aoy Tomita-Mitchell, PhD 

Titles
Investigator, Children's Research Institute; associate professor, Pediatric Surgery, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research interests
Cell and developmental biology, fetal concerns/prematurity diseases, genetic diseases/genomics, heart disease, congenital heart disease, solid organ transplantation.

Study interests
Development and utilization of high-throughput methodologies for identifying inherited risk factors, genetic and molecular etiology of congenital heart disease, mutation detection technologies.

Education
Doctorate, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Pediatric Cardiology, The Children's Hospital of Philadelphia, 2004.

Honors
USA Olympic Intercollegiate Engineering Design competition, first place, Denver, 1993; Ida Green Fellow, Massachusetts Institute of Technology, Cambridge, 1994; Poitras Biomedical Engineering/Biophysics Fellow, Massachusetts Institute of Technology, Cambridge, 1998; Aspen Cancer Conference Fellow, Colo., 1999; The Business Journal's "Forty under 40," 2009.

Representative publications

  • Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME. Multiplexed Quantitative Real-time PCR to Detect 22q11.2 Deletion in Patients with Congenital Heart Disease. Physiol Genomics. 2010 Sep.; 42A(1):52-60.
  • Elizabeth A. Worthey, Alan N. Mayer, Grant D. Syverson, Daniel Helbling, Benedetta B. Bonacci, Brennan Decker, Jaime M. Serpe, Trivikram Dasu, Michael R. Tschannen, Regan L. Veith, Monica J. Basehore, Ulrich Broeckel, Aoy Tomita-Mitchell, James T. Casper, David A. Margolis, David P. Bick, Martin J. Hessner, John  M. Routes, James W. Verbsky, Howard J. Jacob, David P. Dimmock. Successful Clinical Use of Whole Exome Sequencing Identifying a New Genetic Etiology for Inflammatory Bowel Disease. Genetics in Medicine. 2010 Dec. 17.
  • Susan E. Harris, Christine Cronk, Laura Cassidy, Pippa Simpson, Aoy Tomita-Mitchell, Andrew N. Pelech. Exploring the Environmental and Genetic Etiologies of Congenital Heart Defects: the Wisconsin Pediatric Cardiac Registry. Journal of Registry Management. 2011 spring.
  • Sparks AB, Wang ET, Struble CA, Barrett W, Stokowski R, McBride C, Zahn J, Lee K, Shen N, Doshi J, Sun M, Garrison J, Sandler J, Hollemon D, Pattee P, Tomita-Mitchell A, Mitchell M, Stuelpnagel J, Song K, Oliphant A. Selective Analysis of Cell-free DNA in Maternal Blood for Evaluation of Fetal Trisomy. Prenatal Diagnosis. 2012 Jan.; 32(1):3-9.
  • Hidestrand M, Stokowski R, Song K, Oliphant A, Deavers J, Goetsch M, Simpson P, Kuhlman R, Ames M, Mitchell M, Tomita-Mitchell A. Influence of Temperature during Transportation of Cell-free DNA Analysis. Fetal Diagn Ther. 2012; 31(2) 122-8.
  • Tomita-Mitchell A, Mahnke DK, Struble CA, Tuffmell ME, Stamm KD, Hidestrand M, Harris SE, Goetsch MA, Simpson PM, Bick DP, Broeckel U, Pelech AN, Tweddell JS, Mitchell ME. Human Gene Copy Number Spectra Analysis in Congenital Heart Malformations. Physiol Genomics. 2012.

Grants

  • Lymphoproliferative Disorders in Primary Immunodeficiencies, National Institutes of Health (NIH)/National Cancer Institute (NCI), co-investigator (5%), 1/11/11 - 12/31/12.
  • Inflammation and Infection in Acquired and Congenital Cardiovascular Disease, role, key/senior personnel and mentor, 2/1/09 - 1/31/14.
  • Formative Project within the Pilot Phase of the NCS, The National Children's Study - Vanguard Center; role, lead site investigator, Waukesha County Vanguard Site, MCW subaward, 4/1/11 - 3/31/12.

Contact
Children's Research Institute
Room C2445
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2355
Fax: (414) 955-6310
E-mail: amitchell@mcw.edu

Investigator in the areas of: