Aoy Tomita-Mitchell, PhD 

Titles
Investigator, Children's Research Institute; assistant professor, Pediatric Cardiothoracic Surgery, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research center/program
Cardiothoracic Surgery

Research interests
Genetic diseases/genomics, congenital heart disease

Study interests
Development and utilization of high-throughput methodologies for identifying inherited risk factors, genetic and molecular etiology of congenital heart disease, mutation detection technologies.

Education
Doctorate, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Pediatric Cardiology, The Children's Hospital of Philadelphia, 2004.

Honors
USA Olympic Intercollegiate Engineering Design competition, first place, Denver, 1993; Ida Green Fellow, Massachusetts Institute of Technology, Cambridge, 1994; Poitras Biomedical Engineering/Biophysics Fellow, Massachusetts Institute of Technology, Cambridge, 1998; Aspen Cancer Conference Fellow, Colo., 1999; The Business Journal's "Forty under 40," 2009.

Representative publications

• Tomita-Mitchell A, Lin LL, Glover CL, Goodluck-Griffith J, Thilly WG. The Mutational Spectrum of the HPRT Gene from Human T-cells in Vivo Share a Significant Concordant Set of Hotspots With MNNG Treated Human Cells. Cancer Research. 2003; 63:5793-5798.
• Janelle R. Thompson JR, Randa MA, Marcelino LA, Tomita-Mitchell A, Lim E, Polz MF. Diversity and Dynamics of a North Atlantic Coastal Vibrio Community. Applied and Environmental Microbiology. 2004 Jul.; 70(7):4103-10.
• Li-Sucholeiki X-C, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler P-M, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Todd JA, Thilly WG. Detection of Rare DNA Variants in Pools of DNA from Large Populations Using High Throughput Mutational Spectrometry. Mutation Research. 2005 Mar.; 1;570(2):267-80.
• Li-Sucholeiki X-C, Hu G, Perls T, Tomita-Mitchell A, Thilly WG. Scanning the B-globin Gene For Mutations in Large Populations Using Denaturing Capillary and Gel Electrophoresis. Electrophoresis. 2005 Jun.; 26(13):2531-8.
• Li Q, Deka C, Glassner BJ, Arnold K, Li-Sucholeiki XC, Tomita-Mitchell A, Thilly WG, Karger BL. Design of an Automated Multicapillary Instrument With Fraction Collection for DNA Mutation Discovery By Constant Denaturant Capillary Electrophoresis. Journal of Separation Science. 2005 Aug.; 28(12):1375-89.
• Mitchell ME, Sander TL, Klinkner DB, Tomita-Mitchell A. Molecular Basis of Congenital Heart Disease. Seminars in Thoracic and Cardiovascular Surgery. 2007 Fall; 19(3):228-37.
• Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of Heart Disease Associated With Murine and Human GATA4 Mutation. Journal of Molecular and Cellular Cardiology. 2007 Jun. 21.
• Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E. GATA4 Sequence Variants in Patients With Congenital Heart Disease. Journal of Medical Genetics. 2007 Dec.; 44(12):779-83.
• Draus JM, Hauck MA, Austin EH III, Goetsch M, Tomita-Mitchell A, Mitchell ME. Investigation of Somatic NKX2-5 Mutations in Congenital Heart Disease. Journal of Medical Genetics. 2009; 46;115-122.

Grants

• Development of Population-based Screening for Digeorge Syndrome Type1, National Institutes of Health, principal investigator, 11/01/08- 6/31/10.
• Prospective Blinded Validation of a Non-invasive Diagnostic Test for Fetal Chromosomal Abnormalities, A Healthier Wisconsin/Clinical and Translational Science Institute, co-investigator, principal investigator Michael Mitchell, MD, 1/1/09 - 12/31/10.

Contact
Children's Research Institute
Room C2445
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2355
Fax: (414) 955-6310
E-mail: amitchell@mcw.edu