Aoy Tomita-Mitchell, PhD 

Titles
Investigator, Children's Research Institute; assistant professor, Pediatric Cardiothoracic Surgery, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research interests
Development and utilization of high-throughput methodologies for identifying inherited risk factors, genetic and molecular etiology of congenital heart disease, mutation detection technologies.

Education
Doctorate, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Pediatric Cardiology, The Children's Hospital of Philadelphia, 2004.

Honors
USA Olympic Intercollegiate Engineering Design competition, first place, Denver, 1993; Ida Green Fellow, Massachusetts Institute of Technology, Cambridge, 1994; Poitras Biomedical Engineering/Biophysics Fellow, Massachusetts Institute of Technology, Cambridge, 1998; Aspen Cancer Conference Fellow, Colo., 1999.

Representative publications

• Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E. GATA4 Sequence Variants in Patients with Congenital Heart Disease. Journal Medical Genetics. 2007 Dec.; 44(12):779-83.
• Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of Heart Disease Associated with Murine and Human GATA4 Mutation. Journal Molecular Cell Cardiology. 2007.
• Sander TL, Klinkner DB, Tomita-Mitchell A, Mitchell ME. Molecular and Cellular Basis of Congenital Heart Disease. Pediatric Clinics of North America. 2006 Oct.; 53(5):989-1009.
• Li Q, Deka C, Glassner BJ, Arnold K, Li-Sucholeiki XC, Tomita-Mitchell A, Thilly WG, Karger BL. Design of an Automated Multicapillary Instrument with Fraction Collection for DNA Mutation Discovery by Constant Denaturant Capillary Electrophoresis. Journal of Separation Science. 2005 Aug.; 28(12):1375-89.
• Li-Sucholeiki XC, Hu G, Perls T, Tomita-Mitchell A, Thilly WG. Scanning the b-globin Gene for Mutations in Large Populations using Denaturing Capillary and Gel Electrophoresis. Electrophoresis. 2005 Jun.; 26(13):2531-8.
• Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler P-M, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Todd JA, Thilly WG. Detection of Rare DNA Variants in Pools of DNA from Large Populations Using High Throughput Mutational Spectrometry. Mutation Research. 2005 Mar. 1; 570(2):267-80. 
• Janelle R, Thompson JR, Randa MA, Marcelino LA, Tomita-Mitchell A, Lim E, Polz MF. Diversity and Dynamics of a North Atlantic Coastal Vibrio Community. Applied and Environmental Microbiology. 2004 Jul.; 70(7):4103-10.

Grants

• A Non-invasive Diagnostic Test for Fetal Chromosomal Abnormalities, Wallace Coulter Foundation, principal investigator.
• A Rat Model for Congenital Heart Disease, Children's Research Institute, principal investigator.
• A Non-invasive Diagnostic Test for Fetal Chromosomal Abnormalities using Taq-Man, Biotechnology and Bioengineering Center/Medical College of Wisconsin, co-investigator.

Contact
Children's Research Institute
Room C2445
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-2355
Fax: (414) 955-6310
E-mail: amitchell@mcw.edu