Ramani Ramchandran, PhD
Investigator, Children's Research Institute; Professor, Developmental Vascular Biology program and Zebrafish Drug Screening Core, The Medical College of Wisconsin.
Developmental Vascular Biology Program
Cell and developmental biology
Angioblast development in vertebrates, role of axon guidance genes in vascular development, translational disease models in fish.
Doctorate, Medical College of Georgia, Augusta, 1997; post-doctoral fellowship, Harvard Medical School, Boston, 1997-2002.
Batliboi Scholarship Award (bachelor's degree), 1990; Batliboi Scholarship Award (master's degree), 1991; Tata Memorial Scholarship Award, 1992; Graduate Research Assistantship Award, 1992; Third place, Sigma XI, 1997; Listed in "Who's Who Among Students in American Universities and Colleges," 1997; Special Recognition Award from Student Government Association, 1997; Ruth L. Kirchstein National Research Service Award, 2001; National Cancer Institute Scholar Award, 2002; Nominated for Outstanding Mentor Award, NCI, National Institutes of Health, 2004; Listed in Madison, Wis., "Who's Who of Business Leaders and Professionals," 2006; Cash Performance Award, NIH, 2006; Two Year Complimentary Membership to American Association of Anatomist (successful nomination of a Bensley Award Recipient), 2007; The Donald & Judith Alstadt Charitable Research Foundation Award, 2010.
- Makky K, Duvnjak P, Pramanik K, Ramchandran R and Mayer AN. A Whole-Animal Microplate Assay for Metabolic Rate Using Zebrafish. Journal of Bio Molecular Screening. 2008 Dec. 13; (10):960-967. PMID:19029015.
- Jia Y, Wu S-L, Isenberg JS, Sipes JM, Field L, Zeng B, Bandle RW, Ramchandran R, Karger BL, and Roberts DD. Thiolutin Inhibits Endothelial Cell Adhesion by Perturbing Hsp27 Interactions with the Actin Cytoskeleton. Cell Stress and Chaperones. 2010 Mar.15; (2):165-181; PMC2866983.
- Kanungo J, Zhen Y, Amin N, Kaur S, Ramchandran R, and Pant H. Specific Inhibition of Cyclin-dependent Kinase 5 Activity Induces Motor Neuron Development in Vivo 2009. Biochemical and Biophysical Research Communications 386. 2009; 263-267; PMC2758157.
- Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh N, Chun C, Samant G, Zhao B, Garnaas M, Horswill M, Stanhope S, North P, Miao R, Wilkinson G, Affolter M, and Ramchandran R. A Noncoding Antisense RNA at the Tie-1 Locus Regulates Tie-1 Transcript Levels and Function in vivo. Blood. 2010 Jan. 7; 115(1):133-9; PMC2803688.
- Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant G, Horswill M, Chun C, Mukhopadhyay D, Ramchandran R, and Wilkinson G. Ecscr Promotes Angioblast Migration during Vasculogenesis and Enchances kdr Sensitivity. Blood. 2010, Jun. 3;115(22):4614-22; PMC2881497. **Inside Blood commentary on EC-specific Chemotaxis Receptor: a Double-edged Sword, p. 4614.
- Zhao B, Chun C, Liu Z, Horswill M, Pramanik K, Wilkinson G, Ramchandran R. and Miao R. Nogo-B Receptor is Essential for Angiogenesis in Vivo via AKT Pathway. Blood. 2010. Sep. 2; [Epub ahead of print]. PMID: 20813898.
1R01HL090712-01A2 (Ramchandran, R.) 2009-2013 "Roundabout4 signaling in endothelial cells" Role: PI
1R01HL102745-01 (Ramchandran, R.) 2011-2015 "Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebrates" Role: PI
1R01HL112639-01 (Ramchandran, R.) 2011-2016 "Targeting DUSP-5 to Treat Vascular Anomalies" Role: PI
1R01HL108938-01 (Miao, R. and Ramchandran, R.) 2011-2016 "Role of NgBR" Role: Co-I
HL007792 (Harder, D.) 2009-2014 NIH T32 Training Program "Hypertension and Vascular Biology Training Grant" Role: Mentor
1R01HL111582-01 (Wodnicka, M. and Ramchandran, R.) 2012-2017 "Rap1 in VEGF signaling in endothelial cells" Role: Co-I
2R44HL097465-02 (Ferrante, A. and Ramchandran, R.) 2012-2014 "Fully automated angiogenesis drug discovery assay in zebrafish – Phase II" Role: Co-I
NA (Ramchandran, R. and Duffy, K.) 2012-2013 "Molecular crosstalk and matrix metalloproteinases in generalized lymphatic anomaly (GLA) and gorham-stout syndrome (GSS) patients" Role: PIContact
Children's Research Institute
8701 Watertown Plank Road
TBRC CRI C3420
Wauwatosa, WI 53226
Phone: (414) 955-2387
Fax: (414) 955-6325
Investigator in the areas of: