Calvin Williams, MD, PhD

Pediatric rheumatologist, D. B. and Marjorie Reinhart Chair in Rheumatology, Children's Hospital of Wisconsin; associate professor of Pediatrics, section chief, Pediatric Rheumatology, Medical College of Wisconsin

Specialties:

• Rheumatology,
• Immune dysregulation syndromes.

Certifications:

• Pediatric Rheumatology

Education/training:

• MD/PhD: University of California (Irvine, Cal.)
• Internship: Washington University (St. Louis, MO), Pediatrics
• Residency: Washington University (St. Louis, MO), Pediatrics
• Fellowship: Washington University (St. Louis, MO), Pediatric Rheumatology

Employment:

• 1985-1989: Graduate student in Immunology, Laboratory of Dr. George A. Gutman, Department of Microbiology and Molecular Genetics, University of California, Irvine
• 1991-1992: Intern in Pediatrics, St. Louis Children's Hospital, St. Louis, MO
• 1992-1993: Junior pediatric resident, St. Louis Children's Hospital, St. Louis, MO
• 1993-1994: Clinical fellow in Pediatric Immunology and Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO
• 1994-1996: Research fellow in Pediatric Immunology and Rheumatology, Laboratory of Dr. Paul M. Allen, Center for Immunology, Washington University School of Medicine, St. Louis, MO
• 1996-1998: Instructor in Pediatrics, Washington University School of Medicine, St. Louis, MO
• 1997-2000: Director, Rheumatology Service, Shriner's Hospital for Children, St. Louis, MO
• 1998-2002: Assistant professor of Pediatrics, Washington University School of Medicine, St. Louis, MO
• 2002-present: Associate professor of Pediatrics and Section Chief of Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee
• 2003-present: Associate professor of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee

Professional interests:

T cell development, autoimmunity, immunological tolerance, regulatory T cells

Honors, awards, chairs or professional activities:

• 1982: Summer Fellowship, California Foundation for Biochemical Research
• 1989: Earl C. Anthony Dissertation Fellowship
• 1990: MRES Medical Scientist Student Scholarship
• 1992: Vincent P. Carroll, Jr. Memorial Research Award for Outstanding Research
• 1997: Scholar of the Center for Child Health Research at Washington University
• 1998: Basil O'Connor Research Award, March of Dimes
• 2002: D.B. and Marjorie Reinhart Family Foundation Chair in Rheumatology

Professional memberships/societies:

• 2001: Member, American Association of Immunologists
• 2001: Member, American College of Rheumatology
• 2003: Elected member, Society for Pediatric Research

Recent or important publications:

1. Williams, C.B. and Gutman, G.A. T cell receptor beta chain genes in the rat: Availability and pattern of utilization of variable gene segments differs from that in the mouse. J. Immunol. 142:1027-1035, 1989.

2. Chandy, K.G., Williams, C.B., Spencer, R.H., Aguilar, B., Ghanshani, S., Tempel, B.L. and Gutman, G.A. A family of three mouse potassium channel genes with intronless coding regions. Science 247:973-975, 1990.

3. Williams, C.B., Khurana, S. and Gutman, G.A. Duplication of T cell receptor alpha-chain variable gene segments in the rat. Immunogenetics 32:134-137, 1990.

4. Williams, C.B., Blankenhorn, E.P., Byrd, K.E., Levinson, G. and Gutman, G.A. Organization and nucleotide sequence of the rat T cell receptor beta-chain complex. J. Immunol. 146:4406-4413, 1991.

5. Blankenhorn, E.P., Smith, P.D., Williams, C.B., Gutman, G.A. Alleles of the rat T-cell receptor beta chain gene complex. Immunogenetics 35:324-331, 1992.

6. Vidal, K., Hsu, B., Williams, C.B., and Allen, P. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311-1321, 1996.

7. Williams, C.B., and Allen, P.M. The study of self-tolerance using murine hemoglobin as a model self antigen. CIBA Foundation Symposium N. 215 Immunological Tolerance. 1997, Pg. 41-46.

8. Williams, C.B., Vidal, K., Donermeyer, D., Peterson, D.A., White, J.M., Allen, P.M. In Vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery. J. Immunol. 161:128-137, 1998.

9. Basu, D., Williams, C.B., and Allen, P.M. In vivo antagonism of a T cell response by an endogenously expressed ligand. Proc. Natl. Acad. Sci. USA 95:14332-14336, 1998.

10. Williams, C.B., Engle, D.L., Kersh, G.J., White, J.M., and Allen, P.M. A kinetic threshold between negative and positive selection based on the longevity of the TCR-ligand complex. J. Exp. Med. 189:1531-1544, 1999.

11. Plas, D.R., Williams, C.B., Kersh, G.J., White, L.S., White, J.M., Paust, S., Ulyanova, T., Allen, P.M. and Thomas, M.L. The tyrosine phosphatase SHP-1 regulates thymocyte positive selection. J. Immunol. 162:5680-5684, 1999.

12. Marcelino, J., Carpten, J.D., Suwairi, W.M., Gutierrez, O.M., Schwartz, S., Robbins, C., Sood, R., Makalowska, I., Baxevaris, A., Johnstone, B., Laxer, R.M., Zemel, L., Kim, C.A., Herd, J.K., Ihle, J., Williams, C.B., Johnson, M., Ramen, V., Alonso, L.G., Brunoni, D., Gerstein, A., Papadopoulos, N., Bahabri, S.A., Trent, J.M. and Warman, M.L. CACP, encoding a secreted proteoglycan, is mutated in camtodactyly-arthropathy-coxa vara-pericarditis syndrome. Nature Genetics 23:319-322, 1999.

13. Kersh, G.J., Engle, D.L., Williams, C.B., and Allen, P.M. Ligand-specific selection of class II MHC restricted thymocytes in fetal thymic organ culture. J. Immunol. 164:5675-5682, 2000.

14. Raman, V., Blaeser, F., Ho, N., Engle, D.L., Williams, C.B., and Chatila, T.A. Impaired thymocyte positive selection in CamKIV/Gr-deficient mice. J. Immunol. 167:6270-6278. 2001.

15. Haribhai, D., Meyer, M.M., Engle, D.L., White, J.M, and Williams, C.B. A threshold for T cell tolerance to an inducible serum protein J. Immunol. 170:3007-14, 2003.

16. Singh, J., Williams, C.B., and McAlister, W.H. Talo-patello-scaphoid osteolysis, synovitis and short fourth metacarpals in sisters: a new syndrome? Am. J. Med.. Gen. 121A(2):118-25, 2003.

17. Haribhai, D., Edwards, B., Williams, M.L., and Williams, C.B., Functional reprogramming of the primary immune response by T cell receptor antagonism. J. Exp. Med. 200(11);1371-82, 2004.

18. Lin, D., Truong, N., Grossman, W.J., Haribhai, D., Williams, C.B., Wang, J., Martin, M.G., and Chatila, T.A. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116:1106-15, 2005.

19. Haribhai, D., Lin, W., Relland, L.M., Truong, N., *Chatila, T.A., and *Williams, C.B., Regulatory T cells dynamically control the primary immune response to foreign antigen. J. Immunol. (In press, 2007)

* denotes shared corresponding authors