James Verbsky, MD, PhD

Pediatric rheumatologist, Children's Hospital of Wisconsin; assistant professor, Pediatrics (Rheumatology), Medical College of Wisconsin.

Specialties:

• Autoimmunity
• Immune deficiency
• Immune dysregulation syndromes

Certifications:

• Board eligible in Pediatrics
• Board eligible in Pediatric Rheumatology

Education/training:

• MD/PhD: Washington University (St. Louis MO), Immunology
• Internship: St. Louis Children's Hospital (St. Louis, MO), Pediatrics
• Residency: St. Louis Children's Hospital (St. Louis, MO), Pediatrics
• Fellowship: Washington University (St. Louis MO), Pediatric Rheumatology

Employment:

• 2005-present: Assistant professor of Pediatrics, Medical College of Wisconsin

Professional interests:

Autoinflammatory disorders/fever syndromes, systemic onset of juvenile rheumatoid arthritis, immune dysregulation syndromes (IPEX), juvenile dermatomyositis, SLE, inflammatory bowel disease, T regulatory cells, interleukin-10.

Honors, awards, chairs or professional activities:

• Daivd Gilstrap Fellow Award (2004).
• Abbott Scholar Award in Immunology Research (2004)

Recent or important publications:

1. Malone, D. G., J. W. Verbsky, and P. W. Dolan. A Lavage Method For Dynamic Intraarticular Monitoring Of Animal Joints In Situ: Quantification And Release Kinetics Of Histamine After Selective Synovial Mast Cell Activation By Diverse Secretagogues. Journal of Laboratory & Clinical Medicine 1991; 118:269-279.

2. Malone, D. G., A. Vikingsson, J. S. Seebruch, J. W. Verbsky, and P. W. Dolan. In Vivo Effects Of Nonsteroidal Antiinflammatory Drugs On Rat Skin And Synovial Mast Cell-Induced Vasopermeability. Arthritis & Rheumatism 1991; 34: 164-170.

3. Verbsky, J. W., E. A. Bach, Y. F. Fang, L. P. Yang, D. A. Randolph, and L. E. Fields. Expression Of Janus Kinase 3 In Human Endothelial And Other Non-Lymphoid And Non-Myeloid Cells. Journal of Biological Chemistry 1996; 271: 13976-13980.

4. Verbsky, J. W., P. K. Mcallister, and D. G. Malone. Mast Cell Activation In Human Synovium Explants By Calcium Ionophore A23187, Compound 48/80, And Rabbit IgG Anti-Human IgE, But Not Morphine Sulfate. Inflammation Research 1996; 45: 35-41.

5. W. J. Grossman*, Verbsky, J. W*., L. Yang, L. J. Berg, L. E. Fields, D. D. Chaplin, and L. Ratner. Dysregulated Myelopoiesis in Mice Lacking Janus Kinase 3. Blood 1999; 94: 932-939.

6. Verbsky J. W., D. A. Randolph, L. P. Shornick, D. D. Chaplin. Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation. Journal of Immunology 2002; 168: 2475-82.

7. Verbsky J. W., A.J. White. Effective Use of the Recombinant IL-1 Receptor Antagonist Anakinra in Therapy Resistant Systemic Onset Juvenile Rheumatoid Arthritis. Journal of Rheumatology 2004. Journal of Rheumatology 2004, 31:2071-5.

8. Grossman W.J., J.W. Verbsky, B.L. Tollefsen, C. Kemper, J.P. Atkinson, T.J. Ley. Differential Expression of Granzymes A and B in Human PBMCs and Functional Use in Adaptive CD4+ T Regulatory Lymphocytes. Blood 2004, 104:2840-47.

9. Grossman, W.J.*, Verbsky J.W.*, W. Barchet, M. Colonna, J.P. Atkinson, T.J. Ley. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004, 21:589-601.

10. Kemper, C., Verbsky, J.W., Price, J.D.; Atkinson, J.P. T-Cell Stimulation and Regulation: With Complements from CD46. Immunol.Res. 2005, 32:31-44

11. Verbsky, J.W., Grossman, W.J.. Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives. Ann Med. 2006, 38:20-31

12. Verbsky, JW., Grossman, W.J.. Cellular and genetic basis of primary immune deficiencies. Pediatr Clin North Am. 2006 Aug;53(4):649-84.

13. Caudy, A.A., Reddy, S.T., Chatila, T., Atkinson, J.P., Verbsky, J.W.. CD25 deficiency causes an IPEX-like syndrome and defective IL-10 expression from CD4 lymphocytes. Journal of Allergy and Clinical Immunology, in press.

*Denotes co-authorship