Jack Routes, MD

Medical director, Allergy/Immunology, Children's Hospital of Wisconsin; professor, Pediatrics, section chief, Allergy/Immunology, Medical College of Wisconsin.

Specialties:

• Immune deficiency
• Allergy and Immunology

Certifications:

• Internal Medicine
• Allergy and Immunology

Education/training:

• MD: Indiana University (Indianapolis)
• Internship: University of Utah (Salt Lake City), Internal Medicine
• Residency: University of Utah (Salt Lake City), Internal Medicine
• Fellowship: National Jewish Hospital (Denver), Allergy/Immunology
• Fellowship: University of Colorado (Denver), Infectious Disease

Employment:

• 1984-1985: Staff physician, Department of Medicine, L.D.S. Hospital, Salt Lake City, UT
• 1986-1987: Attending physician, Denver General, Internal Medicine Acute Care Clinic, Denver
• 1987-1988: Staff allergist-immunologist (part-time), Kaiser-Permanente Medical Care, Westminster, CO
• 1990-1996: Assistant faculty member, Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Center for Immunology and Respiratory Medicine, Denver
• 1991-1996: Assistant professor of Medicine, Department of Medicine, Division of Allergy and Clinical Immunology University of Colorado Health Sciences Center, Denver.
• 1994-1996: Assistant professor, Department of Immunology, University of Colorado Health Sciences Center, Denver
• 1997-2006: Associate faculty member, Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Center for Immunology and Respiratory Medicine, Denver
• 1997-2006: Associate professor of Medicine, Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Health Sciences Center, Denver
• 1997-2006: Associate professor, Integrated Department of Immunology, NJMRC and, University of Colorado Health Sciences Center, Denver
• 1997-2006: Associate professor, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver
• 1998-2006: Associate professor, Biomedical Sciences Program, University of Colorado Health Sciences Center, Denver
• July 2006- Present: Professor of Pediatrics, Chief, Section of Allergy and Immunology, Department of Pediatrics, Medical College of Wisconsin

Professional interests:

Research interests include the pathogenesis of lymphoproliferative disorders and lung disease in primary immunodeficiencies, in particular common variable immunodeficiency, DNA tumor viruses in human disease and the role of bacterial and viral infections in asthma.

Honors, awards, chairs or professional activities:

• Phi Beta Kappa (1976)
• Alpha Omega Alpha (1980)
• Diplomate - American Board of Internal Medicine (1984)
• Diplomate - American Board of Allergy and Immunology (1987)
• Fred O. Lawson Jr. Fellow in Clinical Immunology (1988)
• Western Society for Clinical Investigation (1994)
• American Cancer Society Junior Faculty Research Award (1995)
• Fellow, American Academy Allergy and Immunology (1998)
• Immunodeficiency Foundation Research Award (2004)
• Editor: Frontiers in Bioscience (2004)
• Basic Science Teacher of the Year Award, Integrated Department of Immunology, NJMRC and UCHSC (2004)
• Contributing Author: Textbook of Respiratory Medicine: Murray/Nadel/Mason/Broaddus - 4th Edition (2005)
• Contributing Author: Methods in Molecular Medicine: Adenovirus Methods and Protocols. Wold and Tollefson-2nd Edition (2005)
• Editor: Immunology Watch (2005-present)

Professional memberships/societies/committees:

National/international

• United States Immunodeficiency Network: Advisory Panel and Registry Committee- (2004-present)
• Pan American Group for Immunodeficiencies (2002-present)
• Working Group for Updating the Practice Parameters for the Diagnosis and Management of Primary Immunodeficiency Diseases-Joint Task Force for Parameter Development of the Joint Council of Allergy, Asthma & Immunology, and the American Academy of Allergy, Asthma, and Immunology (2002-present)
• Joint Task Force on Smallpox Vaccine: Joint Council of Allergy, Asthma & Immunology, and the American Academy of Allergy, Asthma, and Immunology (2003-present)
• Member, NIH Consortium on Primary Immunodeficiencies (2004-present)
• Consultant: FDA Immunologic Devices Panel (5/2006-present)

Recent or important publications:

1. Cool, C., Pradeep R., Yeager, A., Serls, B.,Bull, T., Brown, K., Routes,J.,Tuder, R., and Voelkel, J. Expression of Human Herpes Virus 8 in Primary Pulmonary Hypertension. N. Engl. J. Med. 349:1113-22, 2003.

2. Bates, C.A., Ellison, M.C., Lynch, D.P., Cool, C.D., Brown, K.K., Routes, J.M. Granulomatous or Lymphocytic Interstitial Lung Disease Shortens Survival in Common Variable Immunodeficiency. J. Allergy Clin. Immunol. 114:246-51, 2004.

3. Morimoto, Y. and Routes, J.M. Granulomatous Disease in Common

4. Variable Immunodeficiency. Current Allergy and Asthma Reports, 5(5):370-5, 2005.

5. Bonilla, F., Zallas, B., Chinen, C., Frank, M. Kobrynski , L., Levinson, A., Mazer, B., Nelson, R., Orange, J. Routes, J.M, Shearer, W., Sorenson, R., Zallas, B.(authors listed in alphabetical order) Practice Parameters for the Diagnosis and Management of Primary Immunodeficiencies. Ann. of Allergy, Asthma, and Immunol. 94:S1-S64, 2005.

6. Wheat, W.H., Cool, C.D., Morimoto, Y., Rai, P.R., Kirkpatrick, C.H., Lindenbaum, B.A., Bates, C.A., Ellison, M.C., Serls,A.E., Brown, K.K., Routes, J.M. Role of Human Herpesvirus 8 in the Lymphoproliferative Disorders in Common Variable Immunodeficiency. J. Exp. Med.15;202(4):479-84, 2005.

7. Routes, J.M., Ryan, S.,Takaki, R., Cerwenka,, A., Lanier, L.L. Adenovirus E1A Sensitizes Tumor Cells to NKG2D-dependent NK Cell Lysis and Tumor Rejection. J. Exp. Med. 202(11):477-82, 2005.

8. Miura, T.A., Ryan, S., Cook, J.L., Potter, T.A., Routes, J.M. The interaction of Adenovirus E1A with p300 Family Members Modulates Cellular Gene Expression to Reduce Tumorigenicity. J. Cell Biochem. EPub 2006