William Grossman, MD, PhD

Titles/roles:

Pediatric hematologist/oncologist, Children's Hospital of Wisconsin; assistant professor in Pediatric Hematology/Oncology/Blood & Marrow Transplant, assistant professor in Pediatric Allergy/Clinical Immunology, assistant professor in Microbiology and Molecular Genetics, Medical Director of the Clinical Immunodiagnostic and Research Laboratory - Immunodiagnostics, Medical College of Wisconsin.

Specialties:

• Pediatric Hematology/Oncology/Blood & Marrow Transplant
• Pediatric Allergy/Clinical Immunology

Certifications:

• Pediatrics

Education/training:

• MD/PhD: Washington University (St. Louis, MO), Immunology
• Internship: St. Louis Children's Hospital (St Louis, MO), Pediatrics
• Residency: St. Louis Children's Hospital (St Louis, MO), Pediatrics
• Fellowship: St. Louis Children's Hospital (St Louis, MO), Hematology/Oncology

Employment:

• 1999-2000: Medical internship, Pediatrics, St. Louis Children's Hospital, St. Louis, MO
• 2000-2001: Medical residency, Pediatrics, St. Louis Children's Hospital, St. Louis, MO
• 2001-2004: Fellowship, Pediatric Hematology/Oncology/BMT, St. Louis Children's Hospital, St. Louis, MO
• 2002-2004: Post-doctoral fellow, Pediatrics/Internal Medicine, Washington University, St. Louis, MO
• 2004-present: Assistant professor, Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee
• 2004-present: Medical director, Cell Marker Laboratory Ð Immunodiagnostics Section, Medical College of Wisconsin, Milwaukee
• 2006-present: Assistant professor, Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee
• 2006-present: Assistant professor, Asthma/Allergy/Immunology, Medical College of Wisconsin, Milwaukee

Professional interest:

Primary Immune deficiencies, immune dysregulation, hemophagocytic lymphohistiocytosis (HLH), bone marrow transplantation, graft-vs.-host-disease (GvHD), tumor biology.

Honors, awards, chairs or professional activities:

• The David Gilstrap Memorial Award for Academic Research in Immunology/ Rheumatology, 2003.
• The James P. Keating, M.D. Outstanding Resident Award, 2001
• The Alexander Berg Prize for research in molecular microbiology, 1999
• Spencer T. and Ann W. Olin Medical Scientist Fellow, 1996
• Medical Scientist Training Program, 1992 - 1999
• Magna Cum Laude in Biology and Chemistry
• Scholl Foundation Research Fellowship in Biology and Chemistry
• American Chemical Society Analytical Chemistry Award
• Phi Lambda Upsilon National Honor Society
• Delta Epsilon Sigma National Honor Society
• Beta Beta Beta National Honor Society
• University of St. Thomas Award for Outstanding Undergraduate Research
• Dr. William B. Larson Scholarship in Pre-Med
• Dr. William B. Larson Scholarship in Chemistry
• Dr. Paul J. Germann Scholarship in Biology
• Dean's List six semesters
• Staff Instructor in Advanced Cell Biology, 2005-present, Medical College of Wisconsin
• IVIG Usage Subcommittee, ChildrenÍs Hospital of Wisconsin, 2005-present.
• General Clinical Research Center Review Committte, 2007-present

Professional memberships/societies:

• 1999-present: American Academy of Pediatrics
• 1999-present: American Medical Association
• 2004-present: American Society of Hematology Ð Associate Member
• 2005-present: American Association of Immunologists

Recent or important publications:

1. William J. Grossman, Jason T. Kimata, Fen-Hwa Wong, Mary Zutter, Timothy J. Ley, and Lee Ratner. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. PNAS (USA), 92: 1057-1061 (1995).

2. William J. Grossman and Lee Ratner. Transgenic Mouse Models for HTLV-1 Infection. Journal of Acquired Immune Deficiency Syndromes and Human Retroviruses, 13: 162-169 (1996).

3. William J. Grossman and Lee Ratner. Cytokine Expression and Tumorigenicity of Large Granular Lymphocytic Leukemia Cells From Mice Transgenic for the tax Gene of Human T-Cell Leukemia Virus Type-I. Blood, 90: 783-794 (1997).

4. William J. Grossman, James W. Verbsky, Liping Yang, Larry E. Fields, Leslie J. Berg, David D. Chaplin, and Lee Ratner. Dysregulated Myelopoiesis in Mice Lacking Jak3. Blood, 94: 1-9 (1999).

5. Toni Portis, William J. Grossman, John C. Harding, Jay L. Hess and Lee Ratner. Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model. J. Virol., 75: 2185-2193 (2001).

6. William J. Grossman and Timothy J. Ley. Granzymes A and B are not expressed in human neutrophils. Blood, 104 (3): 906-907 (2004).

7. William J. Grossman, James W. Verbsky, Benjamin L. Tollefson, Claudia Kemper, John P. Atkinson, and Timothy J. Ley. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood, 104 (9): 2840-2848 (2004).

8. William J. Grossman, James W. Verbsky, Winfried Barchet, Marco Colonna, John P. Atkinson, and Timothy J. Ley. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity, 21: 589-601 (2004).

9. Shalini Shenoy, William J. Grossman, John DiPersio, Lolie C. Yu, David Wilson, Yvonne J. Barnes, T. Mohanakumar, and Robert J. Hayashi. A novel reduced intensity stem cell transplant approach for non-malignant disorders. Bone Marrow Tranplant. 35: 345-352 (2005).

10. William J. Grossman, Paula Revell, Doria Thomas, Raj Behl, X. Cao, Z. Lu, and Timothy J. Ley. Granzymes downstream from granzyme B are relevant for cytotoxic lymphocyte functions in vitro and in vivo. J. Immunol., 174: 2124-2131 (2005). (WG, PR, DT, RB, XC, ZL co-first authors)

11. Lin Wen, Nga Truong, William J. Grossman, Dipica Haribhai, Calvin B. Williams, Jiagaeng Wang, Martin G. Martin, Talal A. Chatila. Mechanisms of Allergic Inflammation in Foxp3 Deficient Mice. Journal of Allergy and Clinical Immunology, 16: 1106-1115 (2005).

12. William J. Grossman, Mohammed Radhi, Erick Gerday, Charles Grose, and Frederick D. Goldman. Development of Hemophagocytic Lymphohistiocytosis in Triplets Infected with HHV-8. Blood, 106(4): 1203-1206 (2005).

13. James W. Verbsky and William J. Grossman. Hemophagocytic Lymphohistiocytosis: Diagnosis, pathophysiology, treatment, and future perspectives. Annals of Medicine, 38: 20-31 (2006).

14. James W. Verbsky and William J. Grossman. Cellular and Genetic Basis of Primary Immune Deficiencies. Pediatric Clinics of North America, 53: 649-684 (2006).

15. Aarati Rao, Michael Kelly, Mark Musselman, Jagadeesh Ramadas, David Wilson, William Grossman, Shalini Shenoy. Safety, efficacy and immune reconstitution after Rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. In press (2007).