Jack Routes, MD
Titles
Medical director, Allergy/Immunology, Children's Hospital of Wisconsin; professor, Pediatrics, (Allergy and Immunology), professor, Medicine, (Microbiology and Molecular Genetics), section chief, Allergy and Immunology, The Medical College of Wisconsin.
Division
Asthma, Allergy and Immunology
Research center/program
Cardiothoracic Surgery, Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies
Research interests
Infectious/immunologic diseases
Study interests
Human adenovirus, human papillovirus, lymphoproliferative disorders, primary immunodeficiency.
Education
Medical degree, Indiana University School of Medicine, Indianapolis, 1981; residency, University of Utah, Salt Lake City, 1984; fellowship, Infectious Disease, National Jewish Medical Research Center and the University of Colorado Health Sciences Center, Denver, 1989.
Certifications
American Board of Internal Medicine, American Board of Allergy and Immunology.
Video Profile
Meet Dr. Routes and learn about the Primary Immunodeficiency Program at Children's Hospital of Wisconsin by watching the following video:
Honors
Phi Beta Kappa, 1976; Alpha Omega Alpha, 1980; Diplomate, American Board of Internal Medicine, 1984; Diplomate, American Board of Allergy and Immunology, 1987; Fred O. Lawson, Jr. Fellow in Clinical Immunology, 1988; Western Society for Clinical Investigation, 1994; American Cancer Society Junior Faculty Research Award, 1995; Fellow, American Academy of Allergy, Asthma and Immunology, 1998; member, Pan-American Group for Immunodeficiencies, 2003-present; Selected in "The Best Doctors in America," 2003-present; Working Group for Updating the Practice Parameters for the Diagnosis and Management of Primary Immunodeficiency, AAAAI-ACAI, 2003-present; Immunodeficiency Foundation Research Award, 2004; Basic Science Teacher of the Year Award, Integrated Department of Immunology, NJMRC and UCHSC, 2004; member, NIH Study Section: Infectious Agents in Chronic Lung Disease, 2005; member, Advisory Board: United States Immunodeficiency Network, 2005-present; member, FDA Immunology Devices Panel, 2006-present; member, NIH Study Section: Ancillary Studies in Clinical Trials, 2006-present; Fellow, American College of Asthma, Allergy and Immunology, 2006; member, NIH Study Section: Molecular Oncology, 2007; Councilor, Clinical Immunology Society, 2007-2010.
Representative publications
- Bates CA, Ellison MC, Lynch DP, Cool CD, Brown KK, Routes JM. Granulomatous of Lyumphocytic Interstitial Lung Disease Shortens Survival in Common Variable Immunodeficiency. Journal of Allergy and Clinical Immunology. 2004; 114:246-51.
- Routes JF, Morris K, Ellison M, Ryan S. Macrophages Kill HPV 16-E6-expressing Tumor Cells by TNF- and Nitric Oxide-dependent Mechanisms. Journal of Virology. 2005; 79:116-23.
- Bonilla F, Chinen C, Frank M, Koabrynski L, Levinson A, Mazer B, Nelson R, Orange J, Routes JM, Shearer W, Sorenson R, Zallas B. Practice Parameters for the Diagnosis and Management of Primary Immunodeficiencies. Annals of Allergy, Asthma and Immunology. 2005; 94:S1-S64.
- Wheat WH, Cool CD, Morimoto Y, Rai PR, Kirkpatrick CH, Lindenbaum BA, Bates CA, Ellison MC, Serls, AE, Brown KK, Routes JM. Role of Human Herpesvirus 8 in the Lymphoproliferative Disorders in Common Variable Immunodeficiency. Journal of Experimental Medicine. 2005; 204:479-484.
- Routes JM, Ryan S, Takaki R, Cerwenka A, Lanier LL. Adenovirus ElA Sensitizes Tumor Cells to NKG2D-dependent NK Cell Lysis and Tumor Rejection. Journal of Experimental Medicine. 2005; 202(11):477-82.
- Miura TA, Ryan S, Cook JL, Potter TA, Routes JM. The Interaction of Adenovirus ElA with p300 Family Members Modulates Cellular Gene Expression to Reduce Tumorigencity. Journal of Cellular Biochemistry.
Grants
- Anti-tumorigenic Activity of Adenovirus E1A, principal investigator, National Institutes of Health, RO-1.
- Lymphoproliferative Disorders in Primary Immunodeficiency, principal investigator, NIH RO-1.
- Role of TGF-b and Regulator T-cells in the Anti-tumorigenicity of Decreasing Regualtory T-cell Numbers or Regulator T-cell Function, principal investigator, Medical College of Wisconsin.
Contact
Children's Hospital of Wisconsin
PO Box 1997
Suite 408
Milwaukee, WI 53201-1997
Phone: (414) 266-6840
Fax: (414) 266-6323
E-mail: jroutes@mcw.edu
Investigator in the areas of: