Howard J. Jacob, PhD

Titles
Investigator, Children's Research Institute; professor, Physiology and Pediatrics, associate section chief, Genetics, Medical College of Wisconsin.

Division
Genetics

Research center/program
Cardiothoracic Surgery

Research interests
Genetic diseases/genomics

Study interests
Disease interaction, genetic dissection of complex disease, integrative physiology, physiological genetics.

Education
Doctorate, University of Iowa, Iowa City, 1989; postdoctoral fellow, Hypertension Training Program, Harvard Medical School, Cambridge, Mass., 1991; postdoctoral fellow, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, 1992; postdoctoral fellow, Cardiology, Stanford University, Palo Alto, Calif., 1992.

Honors
Merck, Sharpe and Dohme Travel Award for Outstanding Cardiovascular Research, 1991; Sokol Post Doctoral Fellowship Award, Whitehead Institute for Biomedical Research, 1991; elected fellow in the Council for High Blood Pressure, 1998; American Physiological Society, Bowditch Award and Lecturer (Young Investigator Award), 1999; Warren P. Knowles Chair of Genetics, 1999.

Representative publications

• Lazar J, Moreno C, Jacob HJ, Kwitek, AE. Impact of Genomics on Research in the Rat. Genome Research. 2005 Dec.; 15(12):1717-28.
• Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, FU X, Hassinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL, Sultant R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH. Physiogenomic Resources for Rat Models of Heart, Lung and Blood Disorders. Nature Genetics. 2006 Feb.; 38(2):234-9.
• Kwitek AD, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard Jr KA, Roman RJ, Tonellato PJ, Cowley Jr AW. BN Phenome: Detailed Caracterization of the Crdiovascular, Renal and Pulmonary Systems of the Sequenced Rat. Physiological Genomics. 2006 Apr.; 25(2):303-13.
• Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Synergistic QTL Interactions Between Rf-1 and Rf-3 Inrease Renal Damage Susceptibility in Double Congenic Rats. Kidney International. 2006 Apr.; 69(8):1369-76.
• Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A. Characterization of Blood Pressure and Renal Function in Chromosome 5 Cogenic Strains of Dahl S Rats. American Journal of Physiology. 2006 Jun.; 290(6):F1463-71.

Grants 

• National Institutes of Health, Rat Genetic Mapping Center, SCOR: Molecular Genetics of Hypertension, principal investigator, 1996-2006.
• NIH, Rat Genome Database, principal investigator and co-principal investigator, 1999-2009.
• NIH, Knockout Rats for Physiological Genomics, principal investigator, 2000-2008.
• United States-Israel Bi-National Science Foundation, Study of Differential Gene Expression in the Kidneys of the Sabra Rat, co-principal investigator, 2004-2007.
• United States-Israel Bi-National Science Foundation, Differential Gene Expression in the Dissection of the Pathophysiological Basis of Proteineuria and Glomulo-sclerosis and its Relationship to Salt Susceptibility in the Sabra Rat Model of FSGS, co-principal investigator, 2005-2006.
• NIH, Children's Study Waukesha Vanguard Center, Scientific Advisory Panel, 2005-2010.
• NIH, Genetic Control of BB Rat Autoimmunity, collaborator, 2005-2010.
• Medical College of Wisconsin/Children's Research Institute, Genetics Initiative, principal investigator, 2006-2007.
• Medical College of Wisconsin/Children's Research Institute, Development of an Animal Model of Autosomnal Recessive Polycystic Kidney Disease for Therapy Testing, principal investigator, 2006-2008.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4887
Fax: (414) 456-6516
E-mail: jacob@mcw.edu