John E. Baker, PhD 

Titles
Investigator, Children's Research Institute; professor, Cardiothoracic Surgery, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research center/program
Cardiothoracic Surgery

Research interests
Heart disease

Study interests
Congenital heart disease defects, heart, heart surgery, hypoxia, ischemia, molecular genetics and radiation injury to the heart.

Education
Doctorate, St. Thomas Hospital Medical School, London, 1984; postdoctoral fellowship, Cardiothoracic Surgery, Medical College of Wisconsin, 1986.

 Representative publications

• Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. SCH 79797: A Selective PAR-1 Antagonist, Limits Myocardial Ischemia-reperfusion Injury in Rat Hearts. Basic Research in Cardiology. 2007; 102:350-358.
• Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ. Darbepoetin Alfa Protects the Rat Heart Against Infarction: Dose-response, Phase of Action and Mechanisms. Journal of Cardiovascual Pharmacology. 2007; 49:337-345.
• Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N. Nitrite Confers Protection Against Myocardial Infarction: Role of Xanthine Oxidoreductase, NADPH Oxidase and K_ATP Channels. Journal of Molecular and Cellular Cardiology. 2007; 43:437-444.
• Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE. Gadolinium Limits Myocardial Infarction in the Rat: Dose-response, Temporal Relations and Mechanisms. Journal of Molecular and Cellular Cardiology. 2007.
• Baker JE, Su J, Hsu A, Shi Y, Zhao M, Xu H, Eis A, Komorowski R, Wang J, Fu X, Konorev E, Jensen ES, Tweddell JS, Gross GJ. Human Thrombopoietin Reduces Myocardial Infarctsize, Apoptosis and Stunning Following Ischemia/Reperfusion in Rats. Cardiovascular Research. 2008; 77:44-53.
• Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. Inhibiting Protease-activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling. Journal of Pharmacology and Experimental Therapeutics. (In press) 2008.

Grants

• National Institutes of Health, Chronic Hypoxia and Resistance to Myocardial Ischemia, principal investigator.
• Amgen, Inc., Darbepoetin ALFA and Protection of the Ischemic Heart, principal investigator.
• NIH, Pharmacological Treatment for Radiation Injury, co-investigator.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-8706
Fax: (414) 453-9700
E-mail: jbaker@mcw.edu