John E. Baker, PhD

Titles
Investigator, Children's Research Institute; professor, Cardiothoracic Surgery, Pharmacology & Toxicology, and Biochemistry, Medical College of Wisconsin.

Division
Cardiothoracic Surgery

Research center/program
Cardiovascular Biology

Research interests
Anesthesia, Cancer, genetic diseases/genomics, heart disease, congenital heart disease, solid organ transplantation.

Study interests
Ischemia, hypoxia, heart, molecular genetics, heart surgery and congenital heart defects, radiation injury to the cardiovascular system.

Education
Doctorate, St. Thomas Hospital Medical School, London, 1984; postdoctoral fellowship, Cardiothoracic Surgery, Medical College of Wisconsin, 1986.

Representative publications

Baker JE, Su J, Hsu A, Shi Y, Zhao M, Xu H, Eis A, Komorowski R, Wang J, Fu X, Konorev E, Jensen ES, Tweddell JS, Gross GJ. Human Thrombopoietin Reduces Myocardial Infarctsize, Apoptosis and Stunning Following Ischemia/Reperfusion in Rats. Cardiovascular Research. 2008; 77:44-53.
Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. Inhibiting Protease-activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling. Journal of Pharmacology and Experimental Therapeutics. 2008, 324:1045-1054.
Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Li XA, Hopewell JW, Moulder JE. 10 GY Total Body Irridiation Increases Risk of Coronary Sclerosis, Degeneration of Heart Structure and Function in a Rat Model. International Journal Radiat Biology. 2009, 85:1089-100.
Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N. Nitrite Confers Protection Against Myocardial Infarction: Role of Xanthine Oxidoreductase. NADPH Oxidase and K_ATP channels. Journal Molecular Cell Cardiology. 2007. 43:437-444.
Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ. Darbepoetin Alfa Protects the Rat Heart Against Infarction: Dose-Response, Phase of Action and Mechanisms. Journal Cardiovascular Pharmacology. 2007. 49:337-345.
Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. SCH 79797, a Selective PAR-1 Antagonist, Limits Myocardial Ischemia-Reperfusion Injury in Rat Hearts. Basic Research Cardiology. 2007. 102:350-358.

Grants

National Institutes of Health, Chronic Hypoxia and Resistance to Myocardial Ischemia, principal investigator.
National Institutes of Health, Pharmacological Treatment for Radiation Injury. Allergy and Infectious Diseases, principal investigator.
National Institutes of Health, Radiation Injury to the Heart, Allergy and Infectious Diseases, principal investigator.

Medical College of Wisconsin
Cardiothoracic Surgery
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-8706
Fax: (414) 453-9700
E-mail: jbaker@mcw.edu

Investigator in areas of: