Mary L. Zupanc, MD

Titles
Program director, Pediatric Epilepsy, and The Heidi Marie Bauman Chair in Pediatric Epilepsy, Children's Hospital of Wisconsin; professor, Neurology, Medical College of Wisconsin.

Division
Neurology

Research center/program
Neuroscience research

Research interests
Behavioral health, neuropsychiatric diseases

Study interests
Epilepsy and malformations of cortical development, epilepsy and metabolic disorder, epilepsy and quality of life, epilepsy surgery, genetics of epilepsy, intractable epilepsy-use of Felbamate, investigational drug studies, ketogenic diet, subtraction SPECT.

Education
Medical degree, University of California at Los Angeles, 1979; residency, Pediatrics, University of Washington, School of Medicine/Children's Orthopedic Hospital, Seattle, 1979-1981; Harbor-UCLA Medical Center, Torrance, Calif., 1981-1982; fellowship(s) Pediatric Neurology fellowship, University of Wisconsin Hospitals and Clinics, Departments of Pediatrics and Neurology, Madison, 1982-1985; Neonatal EEG, Stanford University, Palo Alto, Calif., 1986; Magnetoencephalography, Surgical Treatment of Epilepsy, UCLA, 1986.

Certifications
National Medical Board Exam: Part I, II and III; American Board of Pediatrics 1985; American Board of Psychiatry and Neurology with special competence in Child Neurology, 1988; American Board of Clinical Neurophysiology, 1996; American Board of Psychiatry and Neurology with special qualifications in Clinical Neurophysiology, 1996.

Honors
Outstanding Freshman Chemistry Award, University of Wisconsin, 1971; Sigma Epsilon Sigma (Sophomore Women's Honor Society), 1972; Crucible (Junior Women's Honor Society) Honors Convocation Chairperson, 1973; Mortar Board (Senior Women's Honor Society and Service Organization), 1974; Phi Kappa Phi (Honorary Fraternity), 1974; Phi Beta Kappa (Honor Society), 1974; Alpha Omega Alpha (Medical Honor Society), 1978; Stafford L. Warren Medal for Outstanding Academic  Achievement (first in class), 1979; Janet M. Glasgow Award for Outstanding Academic Achievement, American Medical Women's Association (first in class), 1979; selected as one of the Ten Outstanding Young Women in America, 1986; Outstanding Physician Award, Wisconsin Epilepsy Association, 1994; selected as one of the Outstanding Physicians in America, American Health Journal, 1996, 1997, 1998; chosen as one of America's "Best Doctors", 1999, 2000, 2001, 2003, 2004, 2005; Award for Outstanding Clinical Teaching, Department of Pediatrics, University of Wisconsin, Madison, 1990; Clinical Teaching Award, Department of Pediatrics and Adolescent Medicine, Mayo Medical School, Rochester, MN, 1998; Clinical Teaching Award, Department of Pediatrics and Adolescent Medicine, NYU School of Medicine, New York, 1999; Physician of the Year Award, Columbia Presbyterian Hospital, Children's Hospital of New York, 2001; Neurology Clinical Neurophysiology Teaching Award, Medical College of Wisconsin, Milwaukee, 2003; Neurology Clinical Teaching Award, Medical College of Wisconsin, Milwaukee, 2005.

Representative publications

• Meador KJ, Zupanc ML. Neurodevelopment Outcomes of Children Born to Mothers with Epilepsy. Cleveland Clinic Journal of Medicine. 2004; 71(2):S38-41.
• Zupanc ML. Legrow B. Progressive Myoclonic Epilepsy. Cerebellum. 2004; 3(3):156-71.
• Zupanc ML. The First Seizure in Childhood - Don't Just Do Something, Stand There! Neurology. 2005; 64(5):774-775.
• Zupanc ML. Antiepileptic Drugs and Hormonal Contraceptives in Adolescent Women with Epilepsy. Neurology. 2006; 66(3):S37-S45.
• Pellock JM, Faught E, Leppik IE, Shinnar S, Zupanc ML. Felbamate: Consensus of Current Clinical Experience. Epilepsy Research. 2006; 71:89-101.
• Zupanc ML. Treatment of Epilspsy in Infancy and Childhood. Neurology Therapeutics. John Noseworthy, ed. 2007.
• Zupanc ML. Epilepsy in Women: Special Considerations for Adolescents. International Review of Neurobiology. In press.
• Zupanc ML. Sports and Epilepsy. Orthopaedic Sports Medicine: Principles and Practice. DeLee, Drez, and Miller, eds. 3:39-46. In press.
• Zupanc ML, dos Santos Rubio EJ, Werner R, Schwabe M. Epilepsy Surgery Outcomes - Quality of Life and Seizure Control at Children's Hospital of Wisconsin. Submitted for publication.

Grants

• Increasing Access and Awareness of Epilepsy in Underserved Populations, Dept. of Health and Human Services, three years, $250,000/year, principal investigator, 2005-2008.
• Safety and Effectiveness of Open-label Clobazam in Subjects with Lennox-Gastaut Syndrome, Ovation Pharmaceuticals, principal investigator, 2005-present.
• High Dose Cyclophosphamide for the Treatment of Rasmussen's Syndrome: A Pilot Study, principal investigator, 2005-present.
• Functional MRI of Human Brain Language Systems, National Institute of Health/National Institute of Neurological Disorders and Stroke, co-investigator, 2007-present.
• Childhood Absence Epilepsy Study, Multicenter Trial, NIH, co-investigator, 2007-present.
• A Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Safety, Tolerability and Antiepileptic Activity of Ganaxolone in Treatment of Patients with Infantile Spasms, Marinus Pharmaceuticsl, principal investigator, 2007-present.
• An Open-label Clinical Study to Evaluate the Safety and Antiepileptic Activity of Ganaxolone in the Treatment of Patients Diagnosed with Infantile Spasms, Marinus Pharmaceuticals, principal investigator, 2007-present.
• Double-blind, Placebo-controlled, Efficacy and Safety Study of Clobazam (0.25, 0.5 and 1.0 mg/kg/day) in Patients with Lennox-Gastaut Syndrome, Oviation Pharmaceuticals, principal investigator, 2007-present.
• A Multicenter Study of Idiopathic Generalized Epilepsy, Columbia University, study recruiting site, 2007-present.

Contact
Children's Hospital of Wisconsin
PO Box 1997
Milwaukee, WI 53201-1997
Phone: (414) 266-3664
Fax: (414) 266-3466
E-mail: mzupanc@mcw.edu