Mary L. Zupanc, MD

Pediatric Neurology

Title(s): Professor, Department of Neurology and Pediatrics; Heidi Marie Bauman Chair of Epilepsy; chief, Division of Pediatric Neurology; director, Pediatric Comprehensive Epilepsy Program, Medical College of Wisconsin.

Education: Medical degree, University of California at Los Angeles, 1979; residency: Pediatrics, University of Washington, School of Medicine/Children's Orthopedic Hospital, Seattle, 1979-1981; Harbor-UCLA Medical Center, Torrance, Calif., 1981-1982; fellowship(s) Pediatric Neurology fellowship, University of Wisconsin Hospitals and Clinics, Departments of Pediatrics and Neurology, Madison, 1982-1985; Neonatal EEG, Stanford University, 1986; Magnetoencephalography, Surgical Treatment of Epilepsy, UCLA, 1986.

Certification(s):  National Medical Board Exam: Part I, II and III; American Board of Pediatrics 1985; American Board of Psychiatry and Neurology with special competence in Child Neurology, 1988; American Board of Clinical Neurophysiology, 1996; American Board of Psychiatry and Neurology with special qualifications in Clinical Neurophysiology, 1996.

Honors: Outstanding Freshman Chemistry Award, University of Wisconsin, 1971; Sigma Epsilon Sigma (Sophomore Women's Honor Society), 1972; Crucible (Junior Women's Honor Society) Honors Convocation Chairperson, 1973; Mortar Board (Senior Women's Honor Society and Service Organization), 1974; Phi Kappa Phi (Honorary Fraternity), 1974; Phi Beta Kappa (Honor Society), 1974; Alpha Omega Alpha (Medical Honor Society), 1978; Stafford L. Warren Medal for Outstanding Academic  Achievement (first in class), 1979; Janet M. Glasgow Award for Outstanding Academic Achievement, American Medical Women's Association (first in class), 1979; selected as one of the Ten Outstanding Young Women in America, 1986; Outstanding Physician Award, Wisconsin Epilepsy Association, 1994; selected as one of the Outstanding Physicians in America, American Health Journal, 1996, 1997, 1998; chosen as one of America's "Best Doctors", 1999, 2000, 2001, 2003, 2004, 2005; Award for Outstanding Clinical Teaching, Department of Pediatrics, University of Wisconsin, Madison, 1990; Clinical Teaching Award, Department of Pediatrics and Adolescent Medicine, Mayo Medical School, Rochester, MN, 1998; Clinical Teaching Award, Department of Pediatrics and Adolescent Medicine, NYU School of Medicine, New York, 1999; Physician of the Year Award, Columbia Presbyterian Hospital, Children's Hospital of New York, 2001; Neurology Clinical Neurophysiology Teaching Award, Medical College of Wisconsin, Milwaukee, 2003; Neurology Clinical Teaching Award, Medical College of Wisconsin, Milwaukee, 2005.

Research interests: Epilepsy surgery, epilepsy and quality of life, subtraction SPECT, epilepsy and malformations of cortical development, intractable epilepsy-use of Felbamate, genetics of epilepsy, epilepsy and metabolic disorder, ketogenic diet, investigational drug studies.

Representative publications:

• Meador KJ, Zupanc ML. Neurodevelopment Outcomes of Children Born to Mothers with Epilepsy. Cleveland Clinic Journal of Medicine, 2004;71 Suppl 2: S38-41.
• Zupanc ML. Legrow B. Progressive Myoclonic Epilepsy. Cerebellum, 2004;3(3):156-71.
• Zupanc ML. The First Seizure in Childhood-Don't just do Something, Stand There! Neurology, 2005;64(5):774-775.
• Zupanc ML. Antiepileptic Drugs and Hormonal Contraceptives in Adolescent Women with Epilepsy. Neurology 2006, 66 (Suppl 3): S37-S45.
• Pellock JM, Faught E, Leppik IE, Shinnar S, Zupanc ML. Felbamate: Consensus of Current Clinical Experience. Epilepsy Research 2006, 71: 89-101.
• Zupanc ML. Treatment of Epilspsy in Infancy and Childhood. Neurology Therapeutics. John Noseworthy, ed. 2007.
• Zupanc ML. Epilepsy in Women: Special Considerations for Adolescents. International Review of Neurobiology, volume 83. In press.
• Zupanc ML. Sports and Epilepsy. Orthopaedic Sports Medicine: Principles and Practice. DeLee, Drez, and Miller, eds. Chapter 3: 39-46. In press.
• Zupanc ML, dos Santos Rubio EJ, Werner R, Schwabe M. Epilepsy Surgery Outcomes - Quality of Life and Seizure Control at Children's Hospital of Wisconsin. Submitted for publication.

Current grants:

• Increasing Access and Awareness of Epilepsy in Underserved Populations, Dept. of Health and Human Services, 3 years $250,000/year, principal investigator, 2005-2008.
• Safety and Effectiveness of Open-Label Clobazam in Subjects with Lennox-Gastaut Syndrome, Ovation Pharmaceuticals, principal investigator, 2005-present.
• High Dose Cyclophosphamide for the Treatment of Rasmussen's Syndrome: A Pilot Study, principal investigator, 2005-present.
• Functional MRI of Human Brain Language Systems, NIH/NINDS, co-investigator, 2007-present.
• Childhood Absence Epilepsy Study---Multicenter Trial, NIH, co-investigator, 2007-present.
• A Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Tolerability, and Antiepileptic Activity of Ganaxolone in Treatment of Patients with Infantile Spasms, Marinus Pharmaceuticsl, principal investigator, 2007-present.
• An Open-Label Clinical Study to Evaluate the Safety and Antiepileptic Activity of Ganaxolone in the Treatment of Patients Diagnosed with Infantile Spasms, Marinus Pharmaceuticals, principal investigator, 2007-present.
• Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Clobazam (0.25, 0.5 and 1.0 mg/kg/day) in Patients with Lennox-Gastaut Syndrome, Oviation Pharmaceuticals, principal investigator, 2007-present.
• A Multi-Center Study of Idiopathic Generalized Epilepsy, Columbia University, Study recruiting site, 2007-present.

Contact information: Children's Hospital of Wisconsin, 999 North 92nd Street, Wauwatosa, WI 53226. Phone: (414) 266-3664. Fax: (414) 266-3466. E-mail: mzupanc@mcw.edu.