Ronald Hines, PhD

Associate Director

Ronald Hines, PhD, was appointed associate director for Children's Research Institute in September 2005. This position is in addition to his positions at the Medical College of Wisconsin as co-section chief of Clinical Pharmacology, Pharmacogenetics and Teratology; co-director of the Birth Defects Research Center and professor of Pediatrics and Pharmacology and Toxicology. Hines received his bachelor's degree in Zoology from the University of Oklahoma, his Master of Science degree in Natural Sciences from the Roswell Park Division, State University of New York at Buffalo, and his doctorate in Biochemistry from the University of Texas Southwestern Medical School. He then completed a three-year postdoctoral fellowship in molecular biology at the University of Vermont School of Medicine.

In 1983, Hines was appointed assistant professor at the University of Nebraska Medical Center Eppley Cancer Research Institute and Department of Biochemistry. He was promoted to associate professor in 1988. The following year, Wayne State University in Detroit recruited him as an associate professor of Pharmacology. In 1994, he also accepted an associate position within the Department of Pediatrics, Division of Clinical Pharmacology and Toxicology. He was promoted to full professor in 1995. While at Wayne State University, he played an active role in the Environmental Health Science Center, serving as director of the Gene Regulation Research Core from 1994 to 1997 and as the center's deputy director from 1997 to 1999. In 1999, he was recruited to the Medical College of Wisconsin.

Internationally recognized for his expertise in molecular pharmacology and toxicology, Hines served as associate editor for Toxicology and Applied Pharmacology from 1996 to 2004. He serves in the same role for the Journal of Pharmacology, Experimental Therapeutics and Birth Defects Research: Clinical and Molecular Teratology. Hines also serves on the editorial boards for Drug Metabolism and Disposition, Archives of Biochemistry and Biophysics and Chemico Biological Interactions. He has served in leadership roles for both the Society of Toxicology and the American Association of Pharmacology and Experimental Therapeutics and is an active member of the Teratology Society and the American Association of Biochemistry and Molecular Biology. Hines has authored more than 96 original articles in the areas of molecular and developmental pharmacology, molecular toxicology and pharmacogenetics. He is a frequently invited speaker at international and national meetings. Since 1988, Hines has generated more than $9.5 million of extramural research funding for his studies on mechanisms whereby genes involved in drug and toxicant disposition are regulated. Studies have included the impact of environmental toxicant exposure as well as delineating how genetic variability determines disease susceptibility. Most recently, Hines has turned his attention toward understanding how differences in gene expression during development impact life-stage-dependent adverse drug reactions and risk from toxicant exposure.