Nancy J. Wandersee, PhD           

Titles
Investigator, Children's Research Institute; assistant professor, Medical College of Wisconsin.       

Division
Hematology, Oncology and Transplant

Research center/program
Bleeding disorders research

Research interests
Bleeding and blood disorders, Sickle cell anemia, cell and developmental biology, disease pathology

Study interests
Red blood cell membrane/membrane skeleton; hereditary spherocytosis and elliptocytosis; sickle cell disease; hemolysis and vascular injury; mouse models; pathophysiology of stroke, thrombosis and vascular dysfunction.

Education
Doctorate, Genetics, University of Iowa, Iowa City, 1995; post-doctoral fellowship, Red Blood Cell Research, The Jackson Laboratory, Bar Harbor, Maine, 1995-2001.  

Honors
Phi Kappa Phi National Honor Society and Gamma Sigma Epsilon Chemistry Honor Society, 1986; Outstanding Undergraduate Research Award, Sigma Xi Scientific Research Society, 1986; member Sigma Xi Scientific Research Society 1986–present; member American Association for the Advancement of Science, 1997–present; member American Society of Hematology 1998–present.

Representative publications

  • Wandersee NJ, Roesch AN, Hamblen NR, de Moes J, van der Valk MA, Bronson RT, Gimm JA, Mohandas N, Demant P, Barker JE. Defective Spectrin Integrity and Neonatal Thrombosis in the First Mouse Model for Severe Hereditary Elliptocytosis. Blood. 2001; 97:543-550.
  • Wandersee NJ, Olson SC, Holzhauer SL, Hoffmann RG, Barker JE, Hillery CA. Increased Erythrocyte Adhesion in Mice and Humans with Hereditary Spherocytosis and Hereditary Elliptocytosis. Blood. 2004; 103:710-716.
  • Wandersee NJ, Punzalan RC, Rettig MP, Kennedy MD, Pajewski NM, Sabina RL, Scott JP, Low PS, Hillery CA. Erythrocyte Adhesion is Modified by Alterations in Cellular Tonicity and Volume. Br. J. Haem. 2005; 131:366-377.
  • Frei AC, Guo Y, Jones DW, Pritchard KA, Jr., Fagan KA, Hogg N, Wandersee NJ. Vascular Dysfunction in a Murine Model of Severe Hemolysis. Blood. 2008; 112:398-405.  PMCID: PMC2442729.
  • Campanella ME, Chishti A, Wandersee MJ, Peters LL, Narla M, Gilligan D, Low PS. Characterization of Glycolytic Enzyme Interactions with Murine Erythrocyte Membranes in Wild Type and Membrane Protein Knockout Mice. Blood. 2008; 112:3900-3906. PMCID: PMC2572807.
  • Sabina RL, Wandersee MJ, Hillery CA. Ca2+-CaM Activation of AMP Deaminase Contributes to Adenine Nucleotide Dysregulation in Human Sickle Erythrocytes. Br. J. Haem. 2009; 144:434-445. PMCID: PMC2701153.

Grants

  • Nociceptive Mechanisms Underlying Sickle Cell Pain, National Institutes of Health (NIH) (NHLBI/NINDS, co-investigator.
  • Research Project Cooperative (U54 Grant): Midwest Basic and Translational Research Parogram (BTRP), NIH (NHBI), Core Leader (Animal Core), principal investigator (Blood Center subcontract), co-investigator (Project 4: Cell Free Hemoglobin, Lipid Oxidation, and Nitric Oxide in Sickle Cell Disease).
  • Mechanisms of Vascular Injury in Murine Hemolytic Anemia, American Heart Association, National Center Scientist Development Grant, principal investigator.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 937-3815
Fax: (414) 937-6811
E-mail: nancy.wandersee@bcw.edu

Investigator in the areas of: