Xujing Wang, PhD

Endocrinology/Max McGee National Research Center for Juvenile Diabetes          

Title(s): Investigator, Children's Research Institute; associate professor, Pediatrics, Medical College of Wisconsin.

Education: Doctorate, Texas A&M University, College Station, 1995.

Honors: China-U.S. Physics Education Association exam winner, 1988; Theodore Law UCF Scientific Achievement Fellowship, 1997.

Research interests: Mathematical biology, genetics of complex disease and bioinformatics.

Representative publications:

• Wang X, Yang J, Gascoyne PRC. Role of Peroxide in AC Electrical Field Exposure Effects on Friend Murine Erythroleukemia Cells during Dielectrophoretic Manipulations. Biochimestry, Biophysics and Molecular Biology. 1999; Acta 1426(1):53-68.
• Yang J, Huang Y, Wang X, Becker FF, Gascoyne PRC. Dielectric Properties of Human Leukocyte Subpopulations Determined by Electrorotation as a Cell Separation Criterion. Biophysical Journal. 1999; 76:3307-3314.
• Wang X, Ghosh S, Guo SW. Quantitative Quality Control in Microarray Image Processing and Data Acquisition. Nucleic Acids Research. 2001; 29(15):e75.
• Wang X, Becker FF, Gascoyne PRC. Alterations in Membrane Dielectric Responses Precede Surface Expression of PS or DNA-fragmentation in Apoptotic HL-60 Cells. Biochimestry, Biophysics and Molecular Biology. 2002; Acta 1564(2):412-420.
• Wang X, Hessner MJ, Wu Y, Pati N, Ghosh S. Quantitative Quality Control in Microarray Experiment and the Application in Data Filtering, Normalization and False Positive Rate Prediction. Bioinformatics. 2003; 19:1341-1347.
• Wang X, Jia S, Xiang B, Jiang N, Meyer L, Chen Li Y, Moreno-Quinn C, Ghosh S, Jacob HJ, Hessner MJ. Accurate Gene Expression Measurements by cDNA Microarrays Utilizing TDAV. BMC Bioinformatics. 2006; 7(1):378.
• Nittala A, Ghosh S, Stefanovski D, Bergman R, Wang X. Dimensional Analysis of MINMOD Leads to Definition of the Disposition Index and Improved Simulation Algorithm. Biomedical Engineering Online. 2006; 5(44):doi:10.1186/1475-925X-5-44.
• Wang X, He Z, Ghosh S. Investigation of the Age-at-onset Heterogeneity in Type 1 Diabetes through Mathematical Modeling. Mathematical Biosciences. 2006; 203(1):79-99.
• Nittala A, Ghosh S, Wang X. The Oscillatory Insulin Secretion from Pancreatic Islet Depends on its Architecture. PLoS ONE. 2(10): e983, doi:10.1371/journal.pone.0000983, 2007.
• Gao S, Wang X. Topological Analysis of Genetic Networks and Association with Clinical Phenotypes. Bioinformatics. 2007, in press. 

Current grants:

• Genetics of Non-HLA Genes in Post-Adolescent Onset Type 1 Diabetes Mellitus, Juvenile Diabetes Research Foundation, co-investigator.
• High Density Microarrays with Quantitative QC/QA, National Institutes of Health, co-investigator.
• Genetic Dissection of a QTL Affecting the Lipid Profile, NIH, co-investigator.
• Identifying Drug Toxicity Signatures using QC Arrays, NIH/National Cancer Institute, co-investigator.
• Robust T-cell Immunity to Influenza in Human Populations, NIH, co-investigator.
• Role of Leptin in Hormone-resistant Prostate Cancer Cell Growth, Medical College of Wisconsin Cancer Center, co-investigator.

Contact information: Phone: (414) 456-4906. Fax: (414) 456-6663. E-mail: xujing@mcw.edu.