William J. Grossman, MD, PhD

Pediatric Bone Marrow Transplantation

Education: Medical degree, Washington University School of Medicine, St. Louis, Mo., 1999; PhD, Immunology Program, Washington University School of Medicine, St. Louis, 1999; residency, Pediatrics, St. Louis Children's Hospital, St. Louis, 2001; fellowship, Pediatric Hematology/Oncology, St. Louis Children's Hospital, St. Louis, 2004.

Honors: The David Gilstrap Memorial Award for Academic Research in Immunology/ Rheumatology, 2003; The James P. Keating, MD Outstanding Resident Award, 2001; The Alexander Berg Prize for research in molecular microbiology, 1999; Spencer T. and Ann W. Olin Medical Scientist Fellow, 1996; Medical Scientist Training Program, 1992-1999; Hematology Training Grant Award (5T32 HL07088), 1994-1997; Magna Cum Laude in Biology and Chemistry, 1992; Scholl Foundation Research Fellowship in Biology and Chemistry; American Chemical Society Analytical Chemistry Award; Phi Lambda Upsilon National Honor Society; Delta Epsilon Sigma National Honor Society; Beta Beta Beta National Honor Society; University of St. Thomas Award for Outstanding Undergraduate Research; Dr. William B. Larson Scholarship in Pre-Med; Dr. William B. Larson Scholarship in Chemistry; Dr. Paul J. Germann Scholarship in Biology.

Research interests: Primary immune deficiencies, immune dysregulation, hemophagocytic lymphohistiocytosis (HLH), bone marrow transplantation, graft-vs.-host-disease (GVHD) and tumor biology.

Representative publications:

• Grossman WJ, Verbsky JW, Barchet W, Colona M, Atkinson JP, Ley TJ. Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death. Immunity, 21: 589-601 (2004).
• Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential Expression of Granzymes A and B in Human Cytotoxic Lymphocyte Subsets and T Regulatory Cells. Blood, 104 (9): 2840-2848 (2004).
• Grossman WJ, Revell P, Thomas D, Behl R, Cao X, Lu Z, Ley TJ. Granzymes Downstream from Granzyme B are Relevant for Cytotoxic Lymphocyte Functions in vitro and in vivo. Journal of Immunology, 2004.
• Shenoy S, Grossman WJ, DiPersio J, Yu LC, Wilson D, Barnes YJ, Mohanakumar T, Hayashi RJ. A Novel Reduced Intensity Stem Cell Transplant Approach for Non-Malignant Disorders. Bone Marrow Transplant, 2004.
• Grossman WJ, Verbsky JW, Yang L, Fields LE, Berg LJ, Chaplin DD, Ratner L. Dysregulated Myelopoiesis in Mice Lacking Jak3. Blood, 94: 1-9 (1999).
• Grossman WJ, Kimata JT, Wong F-H, Zutter M, Ley TJ, Ratner L. Development of Leukemia in Mice Transgenic for the Tax Gene of Human T-Cell Leukemia Virus Type I. Proceedings of the National Academy of Sciences (USA), 92: 1057-1061 (1995).

Current grants:

• The Role of T Regulatory Cells in Graft-vs.-Host Disease & Tumor Clearance, Advancing a Healthier Wisconsin (Blue Cross/Blue Shield), principal investigator.
• The Role of the Perforin/Granzyme Pathway in T-Regulatory Cells, Hope Street Kids, principal investigator.

Contact information: 8701 Watertown Plank Rd, MFRC Room 5052, Milwaukee, WI 53226. Phone: (414) 456-5789. Fax: (414) 456-6543. E-mail: wgrossma@mcw.edu.