Soumitra Ghosh, MD, PhD

Endocrinology/Max McGee National Research Center for Juvenile Diabetes          

Titles: Associate professor, Wisconsin Medical College; director, Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute.

Education: Medical degree, St. Thomas' Hospital Medical School, London University, 1983; Doctorate of philosophy, Oxford University, St. Edmund Hall, Molecular and Statistical Genetics, 1992; Wellcome Research Fellow in Genetics and Honorary Senior Registrar, Nuffield Department of Surgery & Medicine, John Radcliffe Hospital, Oxford, 1989-1992.

Honors: Plimmer Scholarship in Biochemistry for best student in academic year group of 100 at St. Thomas' Hospital Medical School, 1979; Wellcome Training Fellowship to study for a doctoral degree at the University of Oxford in Molecular and Statistical Genetics, 1989.

Research interests: Genetics in diabetes.

Representative publications:

• Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JS, Hearne CM, et al. Genetic Analysis of Autoimmune Type I Diabetes Mellitus in Mice. Nature 351:542-547, 1991.
• Risch N, Ghosh S, Todd JA. Statistical Evaluation of Multiple-Locus Linkage Data in Experimental Species and its Relevance to Human Studies: Application in NOD Mouse and Human IDDM. American Journal of Human Genetics.. 53:702-714, 1993.
• Ghosh S, Palmer SM, Rodrigues N, Cordell HJ, Hearne CM, Cornall RJ, et al. Polygenic Control of Autoimmune Diabetes in Nonobese Diabetic Mice. Nature Genetics. 4:404-409, 1993.
• Ghosh S, Karanjawala ZE, Hauser ER, Ally D, Knapp JI, Rayman JB, et al. Methods for Precise Sizing, Automated Binning of Alleles and Reduction of Error Rates in Large-Scale Genotyping Using Fluorescently-Labeled Dinucleotide Markers. Genome Research. 7(2):165-178, 1997.
• Ghosh S, Watanabe RM, Valle T, Hauser ER, Magnuson VL, Langefeld CD, et al. The Finland-US Investigation of Non-Insulin Dependent Diabetes Mellitus (FUSION) Genetic Study: An Autosomal Genome Scan for Genes that Predispose to Type 2 Diabetes. American Journal of Human Genetics. 67(5): 1174-1185, 2000.
• Hessner M, Wang X, Hulse K, Meyer L, Wu Y, Nye S, Guo SW, Ghosh S. Three Color cDNA Microarrays: Quantitative Assessment Through the Use of Fluorescein-Labeled Probes. Nucleic Acid Research. 31(4):1-6, 2003.
• Wang X, Hessner M, Wu Y, Pati N, Ghosh S. Quantitative Quality Control in Microarray Experiments and the Application in Data Filtering, Normalization and False Positive Rate Prediction. Bioinformatics. 19(11): 1341-1347 2003 July 22.
• Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh, S. Involvement of Eotaxin, Eosinophils and Pancreatic Predisposition in Development of Type 1 Diabetes Mellitus in the Bio Breeding Rat. Journal of Immunology. 173:6993-7002, 2004.
• Glisic-Milosavljevic S, Waukau J, Jailwala P, Jana S, Khoo HJ, Albertz H, Woodliff J, Koppen M, Alemzadeh R, Hagopian W, Ghosh S. At-Risk and Recent-Onset Type 1 Diabetic Subjects have Increased Apoptosis in the CD4+CD25+^high T-Cell Fraction. Public Library of Science. 2:e146, 2007.
• Glisic-Milosavljevic S, Wang T, Koppen M, Kramer J, Ehlenbach S, Waukau J, Jailwala P, Jana S, Alemzadeh R, Ghosh S. Dynamic Changes in CD4+CD25+high T-Cell Apoptosis after the Diagnosis of Type 1 Diabetes. Clinical and Experimental Immunology. 150(1):75-82, 2007.

Current grants:

• Max McGee National Research Center for Juvenile Diabetes, Children's Hospital and Health System Foundation, principal investigator.
• Genetics of Non-HLA Genes in Post-Adolescent Onset Type 1 Diabetes Mellitus, Juvenile Diabetes Research Foundation, principal investigator.
• Genetics of Autoimmunity in T1DM, American Diabetes Association, principal investigator, pending.

Contact information: 8701 Watertown Plank Road, Department of Pediatrics/HRC #5870, Milwaukee, WI 53226. Phone: (414) 456-4995. Fax: (414) 456-6663. E-mail: sghosh@mcw.edu.