Soumitra Ghosh, MD, PhD       

Education
Medical degree, St. Thomas Hospital Medical School, London University, 1983; doctorate of philosophy, Oxford University, St. Edmund Hall, London, 1992; Wellcome Research Fellow in Genetics and Honorary Senior Registrar, Nuffield Department of Surgery and Medicine, John Radcliffe Hospital, Oxford, London, 1989-1992.

Honors
Plimmer Scholarship in Biochemistry for best student in academic year, St. Thomas Hospital Medical School, 1979; Wellcome Training Fellowship to study for a doctoral degree at the University of Oxford in Molecular and Statistical Genetics, 1989.

Representative publications

• Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JS, Hearne CM, et al. Genetic Analysis of Autoimmune Type I Diabetes Mellitus in Mice. Nature. 1991; 351:542-547.
• Risch N, Ghosh S, Todd JA. Statistical Evaluation of Multiple-locus Linkage Data in Experimental Species and its Relevance to Human Studies: Application in NOD Mouse and Human IDDM. American Journal of Human Genetics. 1993; 53:702-714.
• Ghosh S, Palmer SM, Rodrigues N, Cordell HJ, Hearne CM, Cornall RJ, et al. Polygenic Control of Autoimmune Diabetes in Nonobese Diabetic Mice. Nature. 1993; 4:404-409.
• Ghosh S, Karanjawala ZE, Hauser ER, Ally D, Knapp JI, Rayman JB, et al. Methods for Precise Sizing, Automated Binning of Alleles and Reduction of Error Rates in Large-scale Genotyping Using Fluorescently-labeled Dinucleotide Markers. Genome Research. 1997; 7(2):165-178.
• Ghosh S, Watanabe RM, Valle T, Hauser ER, Magnuson VL, Langefeld CD, et al. The Finland-US Investigation of Non-insulin Dependent Diabetes Mellitus (FUSION) Genetic Study: An Autosomal Genome Scan for Genes that Predispose to Type 2 Diabetes. American Journal of Human Genetics. 2000; 67(5):1174-1185.
• Hessner M, Wang X, Hulse K, Meyer L, Wu Y, Nye S, Guo SW, Ghosh S. Three Color cDNA Microarrays: Quantitative Assessment Through the Use of Fluorescein-Labeled Probes. Nucleic Acid Research. 2003; 31(4):1-6.
• Wang X, Hessner M, Wu Y, Pati N, Ghosh S. Quantitative Quality Control in Microarray Experiments and the Application in Data Filtering, Normalization and False Positive Rate Prediction. Bioinformatics. 2003 Jul. 22; 19(11):1341-1347.
• Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh, S. Involvement of Eotaxin, Eosinophils and Pancreatic Predisposition in Development of Type 1 Diabetes Mellitus in the Bio Breeding Rat. Jounral of Immunology. 2004; 173:6993-7002.
• Glisic-Milosavljevic S, Waukau J, Jailwala P, Jana S, Khoo HJ, Albertz H, Woodliff J, Koppen M, Alemzadeh R, Hagopian W, Ghosh S. At-risk and Recent-onset Type 1 Diabetic Subjects have Increased Apoptosis in the CD4+CD25+high T-cell Fraction. Public Library of Science. 2007; 2:3146.
• Glisic-Milosavljevic S, Wang T, Koppen M, Kramer J, Ehlenbach S, Waukau J, Jailwala P, Jana S, Alemzadeh R, Ghosh S. Dynamic Changes in CD4+CD25+high T-Cell Apoptosis after the Diagnosis of Type 1 Diabetes. Clinical and Experimental Immunology. 2007; 150(1):75-82.

Grants

• Max McGee National Research Center for Juvenile Diabetes, principal investigator, Children's Hospital and Health System Foundation.
• Genetics of Non-HLA Genes in Post-Adolescent Onset Type 1 Diabetes Mellitus, principal investigator, Juvenile Diabetes Research Foundation.
• Genetics of Autoimmunity in T1DM, principal investigator, American Diabetes Association, pending.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4995
Fax: (414) 456-6663
E-mail: sghosh@mcw.edu