D. Gail McCarver, MD

Clinical Pharmacology, Pharmacogenetics and Teratology

Title: Associate professor and co-section chief, Medical College of Wisconsin.

Education: Medical degree, University of Tennessee, Center for the Health Sciences, Memphis, 1978; residency, James Whitcomb Riley Hospital for Children, Indianapolis, 1979-1981; Neonatology fellowship, Section of Neonatal/Perinatal Medicine, Department of Pediatrics, University of Tennessee, Center for the Health Sciences, Memphis; Clinical Pharmacology fellowship, Division of Clinical Pharmacology, Department of Internal Medicine, Vanderbilt University Nashville, Tenn., 1986-1989.

Certification(s): National Board of Medical Examiners, 1979; American Board of Pediatrics (General Pediatrics), 1985; American Board of Pediatrics (Sub-board of Neonatal-Perinatal Medicine), 1987.

Honors: American Academy of Clinical Toxicology Research Award, 1988; Burroughs Wellcome Supplemental Stipend Award, 1988-1989; Society for Pediatric Research-Medical student research program, 1994; Nominated for Teacher of the Year Award-Department of Pediatrics Residency Program, 1996; Society for Pediatric Research-Medical student research program, 1997; Manuscript abstracted and selected for the cover of Alcohol Research  (international journal abstracting the most outstanding articles in scientific literature on alcohol), 1998; Mentored Student Award for Jennifer Yauck, MS, from the Regulatory and Safety Evaluation Specialty Section of the Society of Toxicology, 2003.

Research interests: Exposures in pregnancy, trichloroethylene, organic solvents, alcohol, congenital anomalies, pharmaco/toxicogenetics, environmental health and drug metabolizing enzymes.

Representative publications:

• Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG. Human Hepatic CYP2E1 Expression During Development. The Journal of Pharmacology and Experimental Therapeutics. 307:402-7, 2003.
• Cronk CE, Malloy ME, Pelech AN, Miller RE, Meyer SA, Cowell M, McCarver DG. Completeness of Administrative Databases for Surveillance of Congenital Heart Disease. Birth Defects Research (Part A) 67:597-603, 2003.
• Cronk CE, Pelech AN, Malloy ME, McCarver DG. Birth Prevalence of Hypoplastic Left Heart Syndrome in Wisconsin for Birth Cohorts 1997-99. Birth Defects Research (Part A) 2004.
• Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN. Developmental Expression of Human Hepatic CYP2C9 and CYP2C19. The Journal of Pharmacology and Experimental Therapeutics 308: 965-974, 2004.
• Yauck JS, Malloy ME, Blair K, Simpson PM, McCarver DG. Trichloroethylene and Increased Risk for Congenital Heart Defects. City of Milwaukee, 1997-1999. Birth Defects Research (Part A) 2004.
• Das UG, Martier SS, Simpson PM, McCarver DG. Alcohol Dehydrogenase 2*3 Impacts Alterations in Offspring Facial Morphology Associated with Maternal Ethanol Intake in Pregnancy. Alcoholism: Clinical and Experimental Research 2004.

Current grants:

• Role of CYP2E1 and ADH in Human TRI Teratogenicity, National Institutes of Health, principal investigator.

Contact information: 8701 Watertown Plank Road, Wauwatosa, WI 53226. Phone: (414) 456-4322. Fax: (414) 456-6651. E-mail gmccarver@mcw.edu.